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Literature summary for 2.1.1.63 extracted from

  • Billson, H.A.; Harrison, K.L.; Lees, N.P.; Hall, C.N.; Margison, G.P.; Povey, A.C.
    Dietary variables associated with DNA N7-methylguanine levels and O6-alkylguanine DNA-alkyltransferase activity in human colorectal mucosa (2009), Carcinogenesis, 30, 615-620.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine Homo sapiens
-
 DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal mucosa
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing 6-O-methylguanine + [protein]-L-cysteine
-
 Homo sapiens DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
MGMT
-
 Homo sapiens
O6-alkylguanine DNA-alkyltransferase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens MGMT activity is significantly higher in the group with the lowest consumption of vegetables than in the group with the greatest vegetable consumption up