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Literature summary for 2.1.1.63 extracted from

  • Fahrer, J.; Kaina, B.
    O6-methylguanine-DNA methyltransferase in the defense against N-nitroso compounds and colorectal cancer (2013), Carcinogenesis, 34, 2435-2442.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA (containing 6-O-methylguanine) + protein L-cysteine Homo sapiens
-
DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
?
DNA (containing O6-chloroethylguanine) + protein L-cysteine Homo sapiens
-
DNA (without O6-chloroethylguanine) + protein S-chloroethyl-L-cysteine
-
?
DNA (containing O6-[4-oxo-4-(3-pyridyl)butyl]guanine) + protein L-cysteine Homo sapiens
-
DNA (without O6-[4-oxo-4-(3-pyridyl)butyl]guanine) + protein S-4-oxo-4-(3-pyridyl)butyl-L-cysteine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
Homo sapiens
-
rectum
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA (containing 6-O-methylguanine) + protein L-cysteine
-
Homo sapiens DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
?
DNA (containing O6-chloroethylguanine) + protein L-cysteine
-
Homo sapiens DNA (without O6-chloroethylguanine) + protein S-chloroethyl-L-cysteine
-
?
DNA (containing O6-[4-oxo-4-(3-pyridyl)butyl]guanine) + protein L-cysteine
-
Homo sapiens DNA (without O6-[4-oxo-4-(3-pyridyl)butyl]guanine) + protein S-4-oxo-4-(3-pyridyl)butyl-L-cysteine
-
?

Synonyms

Synonyms Comment Organism
MGMT
-
Homo sapiens
O6-methylguanine-DNA methyltransferase
-
Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme deficiency leads to a tremendously enhanced sensitivity toward alkylation-induced colorectal carcinogenesis Homo sapiens
physiological function the suicide DNA repair protein plays role in the protection against the cytotoxic and mutagenic effects of alkylating agents causing colorectal carcinogenesis Homo sapiens