Literature summary for 2.1.1.63 extracted from

Thirumal Kumar, D.; Mendonca, E.; Priyadharshini Christy, J.; George Priya Doss, C.; Zayed, H.
A computational model to predict the structural and functional consequences of missense mutations in O6-methylguanine DNA methyltransferase (2019), Adv. Protein Chem. Struct. Biol., 115, 351-369 .

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Protein Variants

Protein Variants	Comment	Organism
C145A	the active site mutant shows loss of DNA repair activity	Homo sapiens
R128A	active site mutant	Homo sapiens
R128G	the active site mutant shows loss of DNA repair activity	Homo sapiens
R128K	active site mutant	Homo sapiens
Y114A	active site mutant	Homo sapiens
Y114E	the active site mutant shows loss of DNA repair activity	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
DNA (containing 6-O-methylguanine) + protein L-cysteine	Homo sapiens	-	DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P16455	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA (containing 6-O-methylguanine) + protein L-cysteine	-	Homo sapiens	DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine	-	?

Synonyms

Synonyms	Comment	Organism
MGMT	-	Homo sapiens
O6-methylguanine DNA methyltransferase	-	Homo sapiens

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Release 2023.1 (January 2023)