Literature summary for 2.1.1.63 extracted from

Girot, P.; Dumars, C.; Mosnier, J.F.; Muzellec, L.; Senellart, H.; Foubert, F.; Caroli-Bosc, F.X.; Cauchin, E.; Regenet, N.; Matysiak-Budnik, T.; Touchefeu, Y.
Short article Evaluation of O6-methylguanine-DNA methyltransferase as a predicting factor of response to temozolomide-based chemotherapy in well-differentiated metastatic pancreatic neuroendocrine tumors (2017), Eur. J. Gastroenterol. Hepatol., 29, 826-830 .

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Application

Application	Comment	Organism
medicine	a deficient enzyme status in pancreatic neuroendocrine tumors is not associated with a better response to temozolomide-based chemotherapy and cannot be used as a predictive marker to lead treatment decisions	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
DNA (containing 6-O-methylguanine) + protein L-cysteine	Homo sapiens	-	DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P16455	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA (containing 6-O-methylguanine) + protein L-cysteine	-	Homo sapiens	DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine	-	?

Synonyms

Synonyms	Comment	Organism
MGMT	-	Homo sapiens
O6-methylguanine-DNA methyltransferase	-	Homo sapiens

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Release 2023.1 (January 2023)