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Literature summary for 2.1.1.63 extracted from

  • Cabrini, G.; Fabbri, E.; Lo Nigro, C.; Dechecchi, M.C.; Gambari, R.
    Regulation of expression of O6-methylguanine-DNA methyltransferase and the treatment of glioblastoma (Review) (2015), Int. J. Oncol., 47, 417-428 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.63

Inhibitors

Inhibitors Comment Organism Structure
O6-benzylguanine the pseudosubstrate depletes the enzyme by activating its suicidal dealkylation mechanism Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA (containing 6-O-methylguanine) + protein L-cysteine Homo sapiens
-
 DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell
-
 Homo sapiens
-
glioblastoma cell
-
 Homo sapiens
-
head and neck cancer cell
-
 Homo sapiens
-
LN-340 cell
-
 Homo sapiens
-
lymphoma cell
-
 Homo sapiens
-
non-small cell lung cancer cell
-
 Homo sapiens
-
T-98G cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA (containing 6-O-methylguanine) + protein L-cysteine
-
 Homo sapiens DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
MGMT
-
 Homo sapiens
O6-methylguanine-DNA methyltransferase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens microRNA-603 directly interacts with the 3'-UTR region of enzyme gene and produces a 6fold decrease of both enzyme mRNA and protein upon transfection in glioblastoma cell line in vitro. Downregulation of enzyme expression by microRNA-181d and microRNA-767-3p is due to degradation of the enzyme mRNA. microRNA-221 and microRNA-222 also downregulate the enzyme expression down