Literature summary for 2.1.1.63 extracted from

Kurimoto, T.; Kondo, A.; Ogino, I.; Fujimura, J.; Arakawa, A.; Arai, H.; Shimizu, T.
Effect of O6-methylguanine-DNA methyltransferase methylation in medulloblastoma (2017), Mol. Clin. Oncol., 7, 1107-1111 .

Search for more literature for 2.1.1.63

Application

Application	Comment	Organism
medicine	a larger number of methylated CpG sites in the enzyme promoter region is associated with a favorable outcome of medulloblastoma	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
DNA (containing 6-O-methylguanine) + protein L-cysteine	Homo sapiens	-	DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P16455	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
medulloblastoma cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA (containing 6-O-methylguanine) + protein L-cysteine	-	Homo sapiens	DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine	-	?

Synonyms

Synonyms	Comment	Organism
MGMT	-	Homo sapiens
O6-methylguanine-DNA methyltransferase	-	Homo sapiens

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Release 2023.1 (January 2023)