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Literature summary for 2.1.1.63 extracted from
- Disulfiram sensitizes pituitary adenoma cells to temozolomide by regulating O6-methylguanine-DNA methyltransferase expression (2015), Mol. Med. Rep., 12, 2313-2322 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA (containing 6-O-methylguanine) + protein L-cysteine | Homo sapiens | - |
DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pituitary gland tumor cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DNA (containing 6-O-methylguanine) + protein L-cysteine | - |
Homo sapiens | DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MGMT | - |
Homo sapiens |
| O6-methylguanine-DNA methyltransferase | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | treatment with 0.05 mM disulfiram reduces enzyme protein expression | down |
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Release 2023.1 (January 2023)
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