Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.63 extracted from

  • Chikan, N.A.; Bukhari, S.; Shabir, N.; Amin, A.; Shafi, S.; Qadri, R.A.; Patel, T.N.
    Atomic insight into the altered O6-methylguanine-DNA methyltransferase protein architecture in gastric cancer (2015), PLoS ONE, 10, e0127741 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.63

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA (containing 6-O-methylguanine) + protein L-cysteine Homo sapiens
-
 DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P16455
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gastric cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA (containing 6-O-methylguanine) + protein L-cysteine
-
 Homo sapiens DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
MGMT
-
 Homo sapiens
O6-methylguanine-DNA methyltransferase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the DNA repair protein has an essential role in maintaining genomic stability by removing 6-O-methylguanine adducts Homo sapiens