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Literature summary for 2.1.1.69 extracted from
- O-Methyltransferases of furanocoumarin biosynthesis (1978), Arch. Biochem. Biophys., 188, 272-281.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | - |
Ruta graveolens |  |
| Cu2+ | - |
Ruta graveolens | |
| Fe2+ | - |
Ruta graveolens | |
| kinetin | strong inhibition | Ruta graveolens | |
| Mg2+ | slightly inhibits the O-methylation of bergaptol | Ruta graveolens | |
| Ni2+ | - |
Ruta graveolens | |
| p-chloromercuribenzoic acid | - |
Ruta graveolens | |
| Zn2+ | - |
Ruta graveolens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 110000 | - |
gel filtration | Ruta graveolens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + bergaptol | Ruta graveolens | furanocoumarinbiosynthesis | S-adenosyl-L-homocysteine + bergapten | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Heracleum maximum | - |
Michx. | - |
| Heracleum maximum Michx. | - |
Michx. | - |
| Ruta graveolens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leaf | - |
Heracleum maximum | - |
| leaf | sterile leaf cell culture | Ruta graveolens | - |
| shoot | young shoots of field-grown plants | Ruta graveolens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.000029 | - |
bergaptol | Ruta graveolens |
| 0.000056 | - |
5-hydroxyxanthotoxin | Ruta graveolens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, stored and refrozen, activity against bergaptol is essentially unchanged after 18 days and is still 65% of the initial value after 34 days | Ruta graveolens |
| 0°C, stored below undesalted, 40% loss of activity after 5 weeks | Ruta graveolens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | activity against phenol, resorcinol, phloroglucinol, 3-hydroxy-4-methoxybenzaldehyde, 2-hydroxybenzoic acid, 3-hydroxybenzoic acid, 2-hydroxyphenylacetic acid, 3-hydroxycinnamic acid, and quercetin-7,4'-dimethyl ether lower than 10% of the activity observed with bergaptol as substrate | Ruta graveolens | ? | - |
? | |
| S-adenosyl-L-methionine + 5-hydroxyxanthotoxin | - |
Ruta graveolens | S-adenosyl-L-homocysteine + isopimpinellin | - |
? | |
| S-adenosyl-L-methionine + 5-hydroxyxanthotoxin | - |
Heracleum maximum | S-adenosyl-L-homocysteine + isopimpinellin | - |
? | |
| S-adenosyl-L-methionine + 5-hydroxyxanthotoxin | - |
Heracleum maximum Michx. | S-adenosyl-L-homocysteine + isopimpinellin | - |
? | |
| S-adenosyl-L-methionine + bergaptol | - |
Ruta graveolens | S-adenosyl-L-homocysteine + bergapten | - |
? | |
| S-adenosyl-L-methionine + bergaptol | - |
Heracleum maximum | S-adenosyl-L-homocysteine + bergapten | - |
? | |
| S-adenosyl-L-methionine + bergaptol | furanocoumarinbiosynthesis | Ruta graveolens | S-adenosyl-L-homocysteine + bergapten | - |
? | |
| S-adenosyl-L-methionine + bergaptol | - |
Heracleum maximum Michx. | S-adenosyl-L-homocysteine + bergapten | - |
? | |
| S-adenosyl-L-methionine + caffeic acid | - |
Ruta graveolens | S-adenosyl-L-homocysteine + ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.3 | 8 | - |
Ruta graveolens |
| 8.5 | 9 | 5-hydroxyanthotoxin as substrate | Ruta graveolens |
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