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Literature summary for 2.1.1.8 extracted from

  • Brown, D.D.; Tomchick, R.; Axelrod, J.
    The distribution and properties of a histamine-methylating enzyme (1959), J. Biol. Chem., 234, 2948-2950.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-Bromolysergic acid diethylamide
-
Cavia porcellus
bromo-lysergic acid diethylamide 55% inhibition at 0.005 mM Cavia porcellus
Bufotenine
-
Cavia porcellus
chlorpromazine 60% inhibition at o.oo5 mM Cavia porcellus
chlorpromazine
-
Felis catus
chlorpromazine
-
Mus musculus
chlorpromazine
-
Oryctolagus cuniculus
chlorpromazine
-
Rattus norvegicus
Methylhistamine 40% inhibition at 0.1 mM Cavia porcellus
Methylhistamine
-
Rattus norvegicus
p-chloromercuribenzoate 90% inhibition at 0.01 mM Cavia porcellus
p-chloromercuribenzoate
-
Rattus norvegicus
serotonin 33% inhibition at 0.005 mM Cavia porcellus
serotonin
-
Felis catus
serotonin
-
Mus musculus
serotonin
-
Oryctolagus cuniculus
serotonin
-
Rattus norvegicus
Tubocurare
-
Cavia porcellus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.035
-
histamine
-
Cavia porcellus
0.38
-
S-adenosyl-L-methionine
-
Cavia porcellus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Cavia porcellus
-
-
soluble
-
Mus musculus
-
-
soluble
-
Rattus norvegicus
-
-
soluble
-
Oryctolagus cuniculus
-
-
soluble
-
Felis catus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Cavia porcellus major pathway of histamine metabolism in mammals ?
-
?
additional information Mus musculus major pathway of histamine metabolism in mammals ?
-
?
additional information Rattus norvegicus major pathway of histamine metabolism in mammals ?
-
?
additional information Oryctolagus cuniculus major pathway of histamine metabolism in mammals ?
-
?
additional information Felis catus major pathway of histamine metabolism in mammals ?
-
?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-
Felis catus
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Cavia porcellus

Source Tissue

Source Tissue Comment Organism Textmining
abdomen abdominal skin Cavia porcellus
-
abdomen abdominal skin Mus musculus
-
abdomen abdominal skin Rattus norvegicus
-
abdomen abdominal skin Oryctolagus cuniculus
-
abdomen abdominal skin Felis catus
-
adrenal gland
-
Cavia porcellus
-
adrenal gland
-
Oryctolagus cuniculus
-
adrenal gland
-
Felis catus
-
brain
-
Cavia porcellus
-
brain
-
Mus musculus
-
brain
-
Rattus norvegicus
-
brain
-
Oryctolagus cuniculus
-
brain
-
Felis catus
-
heart
-
Cavia porcellus
-
heart
-
Mus musculus
-
heart
-
Rattus norvegicus
-
heart
-
Oryctolagus cuniculus
-
heart
-
Felis catus
-
ileum
-
Cavia porcellus
-
ileum
-
Rattus norvegicus
-
ileum
-
Oryctolagus cuniculus
-
ileum
-
Felis catus
-
kidney
-
Cavia porcellus
-
kidney
-
Mus musculus
-
kidney
-
Rattus norvegicus
-
kidney
-
Oryctolagus cuniculus
-
kidney
-
Felis catus
-
liver
-
Cavia porcellus
-
liver
-
Mus musculus
-
liver
-
Oryctolagus cuniculus
-
liver
-
Felis catus
-
liver not in rat Rattus norvegicus
-
lung
-
Cavia porcellus
-
lung
-
Mus musculus
-
lung
-
Oryctolagus cuniculus
-
lung
-
Felis catus
-
lung not in rat Rattus norvegicus
-
pancreas
-
Felis catus
-
sciatic nerve
-
Cavia porcellus
-
sciatic nerve
-
Oryctolagus cuniculus
-
sciatic nerve
-
Felis catus
-
spleen
-
Cavia porcellus
-
spleen
-
Mus musculus
-
spleen
-
Oryctolagus cuniculus
-
spleen
-
Felis catus
-
spleen not in rat Rattus norvegicus
-
stomach
-
Cavia porcellus
-
stomach
-
Mus musculus
-
stomach
-
Oryctolagus cuniculus
-
stomach
-
Felis catus
-
thigh muscle
-
Cavia porcellus
-
thigh muscle
-
Mus musculus
-
thigh muscle
-
Rattus norvegicus
-
thigh muscle
-
Oryctolagus cuniculus
-
thigh muscle
-
Felis catus
-
trachea
-
Cavia porcellus
-
trachea
-
Felis catus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
25.4
-
-
Cavia porcellus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information major pathway of histamine metabolism in mammals Cavia porcellus ?
-
?
additional information major pathway of histamine metabolism in mammals Mus musculus ?
-
?
additional information major pathway of histamine metabolism in mammals Rattus norvegicus ?
-
?
additional information major pathway of histamine metabolism in mammals Oryctolagus cuniculus ?
-
?
additional information major pathway of histamine metabolism in mammals Felis catus ?
-
?
S-adenosyl-L-methionine + histamine
-
Cavia porcellus S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
?
S-adenosyl-L-methionine + histamine
-
Mus musculus S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
?
S-adenosyl-L-methionine + histamine
-
Rattus norvegicus S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
?
S-adenosyl-L-methionine + histamine
-
Oryctolagus cuniculus S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
?
S-adenosyl-L-methionine + histamine
-
Felis catus S-adenosyl-L-homocysteine + Ntau-methylhistamine
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Cavia porcellus
37
-
assay at Mus musculus
37
-
assay at Rattus norvegicus
37
-
assay at Oryctolagus cuniculus
37
-
assay at Felis catus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2 7.4
-
Cavia porcellus
7.2 7.4
-
Mus musculus