Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-serine | - |
Homo sapiens | |
tetrahydrofolate | isoform SHMT2 maintains a pronounced tetrahydrofolate substrate inhibition even at the alkaline pH characteristic of the mitochondrial matrix | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.032 | - |
tetrahydrofolate | isoform SHMT2, at pH 7.8 and 30°C | Homo sapiens | |
0.033 | - |
tetrahydrofolate | isoform SHMT1, at pH 7.2 and 30°C | Homo sapiens | |
0.223 | - |
tetrahydrofolate | isoform SHMT2, at pH 7.2 and 30°C | Homo sapiens | |
0.291 | - |
5,10-methylenetetrahydrofolate | isoform SHMT1, at pH 8.8 and 30°C | Homo sapiens | |
0.45 | - |
L-serine | isoform SHMT2, at pH 7.8 and 30°C | Homo sapiens | |
0.556 | - |
glycine | isoform SHMT1, at pH 8.8 and 30°C | Homo sapiens | |
0.66 | - |
glycine | isoform SHMT2, at pH 8.8 and 30°C | Homo sapiens | |
0.98 | - |
5,10-methylenetetrahydrofolate | isoform SHMT2, at pH 8.8 and 30°C | Homo sapiens | |
2.2 | - |
L-serine | isoform SHMT2, at pH 7.2 and 30°C | Homo sapiens | |
4.8 | - |
L-serine | isoform SHMT1, at pH 7.2 and 30°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | isoform SHMT1 | Homo sapiens | 5829 | - |
mitochondrion | isoform SHMT2 | Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + glycine + H2O | Homo sapiens | - |
tetrahydrofolate + L-serine | - |
r | |
tetrahydrofolate + L-serine | Homo sapiens | - |
5,10-methylenetetrahydrofolate + glycine + H2O | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P34896 | - |
- |
Homo sapiens | P34897 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + glycine + H2O | - |
Homo sapiens | tetrahydrofolate + L-serine | - |
r | |
tetrahydrofolate + L-serine | - |
Homo sapiens | 5,10-methylenetetrahydrofolate + glycine + H2O | - |
r |
Synonyms | Comment | Organism |
---|---|---|
serine hydroxymethyltransferase | - |
Homo sapiens |
SHMT1 | isoform | Homo sapiens |
SHMT2 | isoform | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.188 | - |
glycine | isoform SHMT1, at pH 8.8 and 30°C | Homo sapiens | |
6.23 | - |
tetrahydrofolate | isoform SHMT1, at pH 7.2 and 30°C | Homo sapiens | |
13.55 | - |
tetrahydrofolate | isoform SHMT2, at pH 7.8 and 30°C | Homo sapiens | |
14.17 | - |
tetrahydrofolate | isoform SHMT2, at pH 7.2 and 30°C | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Homo sapiens |
8.5 | - |
- |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.258 | - |
tetrahydrofolate | isoform SHMT1, at pH 7.2 and 30°C | Homo sapiens | |
0.368 | - |
L-serine | isoform SHMT1, at pH 7.2 and 30°C | Homo sapiens | |
0.602 | - |
L-serine | isoform SHMT2, at pH 7.8 and 30°C | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.33 | - |
glycine | isoform SHMT1, at pH 8.8 and 30°C | Homo sapiens | |
0.52 | - |
5,10-methylenetetrahydrofolate | isoform SHMT2, at pH 8.8 and 30°C | Homo sapiens | |
0.65 | - |
5,10-methylenetetrahydrofolate | isoform SHMT1, at pH 8.8 and 30°C | Homo sapiens | |
0.77 | - |
glycine | isoform SHMT2, at pH 8.8 and 30°C | Homo sapiens | |
1.33 | - |
L-serine | isoform SHMT1, at pH 7.2 and 30°C | Homo sapiens | |
6.5 | - |
L-serine | isoform SHMT2, at pH 7.2 and 30°C | Homo sapiens | |
30.17 | - |
L-serine | isoform SHMT2, at pH 7.8 and 30°C | Homo sapiens | |
63.5 | - |
tetrahydrofolate | isoform SHMT2, at pH 7.2 and 30°C | Homo sapiens | |
188.83 | - |
tetrahydrofolate | isoform SHMT1, at pH 7.2 and 30°C | Homo sapiens | |
423.33 | - |
tetrahydrofolate | isoform SHMT2, at pH 7.8 and 30°C | Homo sapiens |