Literature summary for 2.1.2.1 extracted from

Saint-Marc, C.; Huerlimann, H.C.; Daignan-Fornier, B.; Pinson, B.
Serine hydroxymethyltransferase a key player connecting purine, folate and methionine metabolism in Saccharomyces cerevisiae (2015), Curr. Genet., 61, 633-640 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5,10-methylenetetrahydrofolate + glycine + H2O	Saccharomyces cerevisiae	-	tetrahydrofolate + L-serine	-	r
5,10-methylenetetrahydrofolate + glycine + H2O	Saccharomyces cerevisiae BY4741	-	tetrahydrofolate + L-serine	-	r
tetrahydrofolate + L-serine	Saccharomyces cerevisiae	-	5,10-methylenetetrahydrofolate + glycine + H2O	-	r
tetrahydrofolate + L-serine	Saccharomyces cerevisiae BY4741	-	5,10-methylenetetrahydrofolate + glycine + H2O	-	r

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-
Saccharomyces cerevisiae BY4741	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,10-methylenetetrahydrofolate + glycine + H2O	-	Saccharomyces cerevisiae	tetrahydrofolate + L-serine	-	r
5,10-methylenetetrahydrofolate + glycine + H2O	-	Saccharomyces cerevisiae BY4741	tetrahydrofolate + L-serine	-	r
tetrahydrofolate + L-serine	-	Saccharomyces cerevisiae	5,10-methylenetetrahydrofolate + glycine + H2O	-	r
tetrahydrofolate + L-serine	-	Saccharomyces cerevisiae BY4741	5,10-methylenetetrahydrofolate + glycine + H2O	-	r

Synonyms

Synonyms	Comment	Organism
serine hydroxymethyltransferase	-	Saccharomyces cerevisiae
SHM2	-	Saccharomyces cerevisiae

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Saccharomyces cerevisiae

Expression

Organism	Comment	Expression
Saccharomyces cerevisiae	5-amino-4-imidazole carboxamide ribonucleotide 5'-phosphate stimulates the transcriptional expression of the enzyme	up

General Information

General Information	Comment	Organism
metabolism	Shm2 is a key enzyme at the crossing point between purine, methionine and folate metabolism	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)