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Literature summary for 2.1.2.2 extracted from

  • Shim, J.H.; Benkovic, S.J.
    Evaluation of the kinetic mechanism of Escherichia coli glycinamide ribonucleotide transformylase (1998), Biochemistry, 37, 8776-8782.
    View publication on PubMed
Search for more literature for 2.1.2.2

Cloned(Commentary)

Cloned (Comment) Organism
second GAR transformylase encoded by the Escherichia coli purT gene Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0123
-
 10-formyl-5,8-dideazafolate
-
 Escherichia coli
0.019
-
 5,8-Dideazafolate
-
 Escherichia coli
0.102
-
 formyl-beta-glycinamide ribonucleotide
-
 Escherichia coli
0.118
-
 beta-glycinamide ribonucleotide
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Homo sapiens
-
 tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Mus musculus third step in de novo purine biosynthetic pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide Escherichia coli third step in de novo purine biosynthetic pathway tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens
-
 human
-
Mus musculus
-
 mouse
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Mus musculus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Escherichia coli tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 r
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide
-
 Homo sapiens tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide third step in de novo purine biosynthetic pathway Mus musculus tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 ?
10-formyltetrahydrofolate + 5-phospho-D-ribosylglycinamide third step in de novo purine biosynthetic pathway Escherichia coli tetrahydrofolate + 5'-phosphoribosyl-N-formylglycinamide
-
 r
acetate + ATP novel non-folate glycinamide ribonucleotide transformylase purT gene product, no significant homology to known EC 2.1.2.2 but significant homology to the purK protein also involved in purine biosynthesis Escherichia coli acetyl phosphate + ADP
-
 ?
additional information trifunctional enzyme, GAR synthetase, aminoimidazole ribonucleotide synthetase and GAR transformylase Mus musculus ?
-
 ?
additional information trifunctional enzyme, GAR synthetase, aminoimidazole ribonucleotide synthetase and GAR transformylase Homo sapiens ?
-
 ?