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Literature summary for 2.1.2.3 extracted from
- Human AICAR transformylase: Role of the 4-Carboxamide of AICAR in binding and catalysis (2000), Biochemistry, 39, 11303-11311.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | target for development of inhibitors with potential use as chemotherapeutic agents | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-N-allyl-5-aminoimidazole-4-carboxamide ribonucleotide | - |
Homo sapiens |  |
| 4-N-methyl-5-aminoimidazole-4-carboxamide ribonucleotide | - |
Homo sapiens | |
| 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | product inhibitor | Homo sapiens | |
| 5-amino-1-beta-D-ribofuranosylimidazole 5'-phosphate | - |
Homo sapiens | |
| 5-amino-1-beta-D-ribofuranosylimidazole-4-carbonitrile 5'-phosphate | - |
Homo sapiens | |
| 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxamidoxime 5'-phosphate | - |
Homo sapiens | |
| 5-amino-1-beta-D-ribofuranosylimidazole-4-carboxylate 5'-phosphate | - |
Homo sapiens | |
| 5-amino-4-nitro-1-beta-D-ribofuranosylimidazole 5'-phosphate | - |
Homo sapiens | |
| 5-formyl-5-aminoimidazole-4-carboxamide ribonucleotide | - |
Homo sapiens | |
| AMP | - |
Homo sapiens | |
| XMP | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0009 | - |
5-amino-imidazole-4-thiocarboxamide ribonucleotide | 10-formyldihydrofolate as cofactor | Homo sapiens | |
| 0.0015 | - |
5-aminoimidazole-4-carboxamide ribonucleotide | 10-formyldihydrofolate as cofactor | Homo sapiens | |
| 0.0019 | - |
5-aminoimidazole-4-carboxamide ribonucleotide | 10-formyltetrahydrofolate as cofactor | Homo sapiens | |
| 0.01 | - |
5-aminoimidazole-4-carboxamide ribonucleotide | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Escherichia coli | - |
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
| 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | Homo sapiens | - |
tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
human | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | - |
Escherichia coli | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
| 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide | - |
Homo sapiens | tetrahdrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide | - |
r | |
| 10-formyltetrahydrofolate + 5-amino-imidazole-4-thiocarboxamide ribonucleotide | - |
Homo sapiens | tetrahydrofolate + 6-mercaptopurine ribonucleotide | - |
? | |
| additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Escherichia coli | ? | - |
? | |
| additional information | in all organisms studied to date AICARFT activity is accompanied by inosine monophosphate cyclohydrolase located on the same polypeptide encoded by the purH gene | Homo sapiens | ? | - |
? | |
| N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Escherichia coli | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r | |
| N10-formyltetrahydrofolic acid + 5-amino-4-imidazole carboxamide ribonucleotide | - |
Homo sapiens | tetrahydrofolic acid + 5-formamido-4-imidazole carboxamide ribonucleotide | - |
r | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| 10-formyldihydrofolate | - |
Homo sapiens | |
| 10-formylfolate | - |
Homo sapiens | |
| N10-formyltetrahydrofolate | - |
Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0004 | - |
5-formyl-5-aminoimidazole-4-carboxamide ribonucleotide | - |
Homo sapiens | |
| 0.0007 | - |
5-amino-4-nitroimidazole ribonucleotide | - |
Homo sapiens | |
| 0.0007 | - |
5-amino-4-nitro-1-beta-D-ribofuranosylimidazole 5'-phosphate | - |
Homo sapiens | |
| 0.0012 | - |
XMP | - |
Homo sapiens | |
| 0.006 | - |
5-amino-1-beta-D-ribofuranosylimidazole 5'-phosphate | - |
Homo sapiens | |
| 0.01 | - |
5-amino-1-beta-D-ribofuranosylimidazole-4-carboxylate 5'-phosphate | - |
Homo sapiens | |
| 0.026 | - |
5-amino-1-beta-D-ribofuranosylimidazole-4-carbonitrile 5'-phosphate | - |
Homo sapiens | |
| 0.027 | - |
AMP | - |
Homo sapiens | |
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