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Literature summary for 2.1.2.5 extracted from

  • Bashour, A.M.; Bloom, G.S.
    58K, a microtubule-binding Golgi protein, is a formiminotransferase cyclodeaminase (1998), J. Biol. Chem., 273, 19612-19617.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
cDNA encoding formiminotransferase cyclodeaminase is cloned and sequenced Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi membrane formiminotransferase cyclodeaminase, 58K, is associated with the cytoplasmic surface of the Golgi apparatus in vivo, cytoplasmically oriented peripheral membrane protein of the Golgi membranes Rattus norvegicus 139
-
microtubule formiminotransferase cyclodeaminase binds bovine brain microtubules, but not rat liver microtubules in vitro Rattus norvegicus 5874
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
480000
-
approximately, native octameric bifunctional enzyme with formiminotransferase and cyclodeaminase activity, EC 2.1.2.5 and EC 4.3.1.4 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-formiminoglutamate + tetrahydrofolate Rattus norvegicus bifunctional formiminotransferase cyclodeaminase, 58K, is associated with the cytoplasmatic surface of the Golgi apparatus in vivo 5-formiminotetrahydrofolate + L-glutamate
-
?
N-formiminoglutamate + tetrahydrofolate Rattus norvegicus histidine metabolism pathway, reaction occurs in vivo within the soluble phase of cytoplasm 5-formiminotetrahydrofolate + L-glutamate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver richest tissue source of formiminotransferase cyclodeaminase, liver-specific enzyme Rattus norvegicus
-
additional information undetectable in adrenal gland, blood cells, marrow cells, brain, epididymis, heart, small intestine, kidney, lung, skeletal muscle, spleen and testis Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
7
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information 58K: formiminotransferase cyclodeaminase, bifunctional enzyme catalyzing two consecutive steps in the modification of tetrahydrofolate to 5,10-methenyl tetrahydrofolate Rattus norvegicus ?
-
?
N-formiminoglutamate + tetrahydrofolate bifunctional formiminotransferase cyclodeaminase, 58K, is associated with the cytoplasmatic surface of the Golgi apparatus in vivo Rattus norvegicus 5-formiminotetrahydrofolate + L-glutamate
-
?
N-formiminoglutamate + tetrahydrofolate histidine metabolism pathway, reaction occurs in vivo within the soluble phase of cytoplasm Rattus norvegicus 5-formiminotetrahydrofolate + L-glutamate
-
?
tetrahydrofolate + N-formimino-L-glutamate transfer of a single carbon from formiminoglutamate to tetrahydrofolate, product is 5-formiminotetrahydrofolate Rattus norvegicus 5-formiminotetrahydrofolate + L-glutamate
-
?

Subunits

Subunits Comment Organism
homooctamer bifunctional formiminotransferase cyclodeaminase Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
tetrahydrofolate
-
Rattus norvegicus