Literature summary for 2.1.3.2 extracted from

Sato, T.; Akasu, H.; Shimono, W.; Matsu, C.; Fujiwara, Y.; Shibagaki, Y.; Heard, J.J.; Tamanoi, F.; Hattori, S.
Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity (2015), J. Biol. Chem., 290, 1096-1105.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	mTOR-dependent phosphorylation occurs at a site located between the dihydroorotase and aspartate transcarbamoylase domains	Mus musculus

Synonyms

Synonyms	Comment	Organism
aspartate transcarbamoylase	-	Mus musculus

General Information

General Information	Comment	Organism
additional information	Rheb binds CAD in a GTP- and effector domain-dependent manner. The region of CAD where Rheb binds is located at the C-terminal region of the carbamoyl-phosphate synthetase domain and not in the dihydroorotase and aspartate transcarbamoylase domains. Rheb stimulated carbamoyl-phosphate synthetase activity of CAD in vitro. CAD binding is more pronounced with Rheb2 than with Rheb1	Mus musculus
physiological function	CAD protein, formed by carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase, is a multifunctional enzyme required for the de novo synthesis of pyrimidine nucleotides. Aspartate transcarbamoylase is located at the C-terminal part of CAD, Each activity is coded in a separate domain	Mus musculus

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Release 2023.1 (January 2023)