Literature summary for 2.1.3.3 extracted from

Sainz, G.; Tricot, C.; Foray, M.F.; Marion, D.; Dideberg, O.; Stalon, V.
Kinetic studies of allosteric catabolic ornithine carbamoyltransferase from Pseudomonas aeruginosa (1998), Eur. J. Biochem., 251, 528-533.

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Activating Compound

Activating Compound	Comment	Organism	Structure
ADP	10 mM, 350% arsenolytic cleavage activity	Pseudomonas aeruginosa
AMP	10 mM, 550% arsenolytic cleavage activity, activation by phosphate and AMP correspond to different mechanisms	Pseudomonas aeruginosa
CMP	10 mM, 340% arsenolytic cleavage activity	Pseudomonas aeruginosa
CTP	10 mM, 340% arsenolytic cleavage activity	Pseudomonas aeruginosa
GMP	10 mM, 340% arsenolytic cleavage activity	Pseudomonas aeruginosa
phosphate	10 mM, 225% arsenolytic cleavage activity	Pseudomonas aeruginosa
UMP	10 mM, 600% arsenolytic cleavage activity	Pseudomonas aeruginosa

Inhibitors

Inhibitors	Comment	Organism	Structure
ADP	-	Pseudomonas aeruginosa
AMP	-	Pseudomonas aeruginosa
ATP	-	Pseudomonas aeruginosa
CMP	-	Pseudomonas aeruginosa
CTP	-	Pseudomonas aeruginosa
GMP	-	Pseudomonas aeruginosa
GTP	-	Pseudomonas aeruginosa
spermidine	10 mM, more than 98% inhibition of arsenolytic cleavage activity	Pseudomonas aeruginosa
UTP	-	Pseudomonas aeruginosa

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	catabolic ornithine carbamoyltransferase	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arsenate + L-citrulline	pseudo-reverse reaction, arsenate is first coupled to citrulline, followed by elimination of carbamoylarsenate	Pseudomonas aeruginosa	carbamoylarsenate + L-ornithine	-	r

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Release 2023.1 (January 2023)