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Literature summary for 2.1.3.3 extracted from

  • Schneider, J.; Eberhardt, D.; Wendisch, V.F.
    Improving putrescine production by Corynebacterium glutamicum by fine-tuning ornithine transcarbamoylase activity using a plasmid addiction system (2012), Appl. Microbiol. Biotechnol., 95, 169-178.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
additional information construction of the putrescine-producing strain PUT1 by deletion of argF, the gene for ornithine transcarbamoylase, and argR, encoding the L-arginine repressor, combined with heterologous expression of the Escherichia coli gene for L-ornithine decarboxylase SpeC. The strain requires supplementation of L-arginine and shows growth-decoupled putrescine production. By fine-tuning argF expression through modifications of the promoter, the translational start codon and/or the ribosome binding site, high productivity and titer can be obtained, optimization of putrescine production by mutant strains, overview Corynebacterium glutamicum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
carbamoyl phosphate + L-ornithine Corynebacterium glutamicum
-
 L-citrulline + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Corynebacterium glutamicum
-
 gene argF
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbamoyl phosphate + L-ornithine
-
 Corynebacterium glutamicum L-citrulline + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
ArgF
-
 Corynebacterium glutamicum
ornithine transcarbamoylase
-
 Corynebacterium glutamicum
OTC
-
 Corynebacterium glutamicum

General Information

General Information Comment Organism
metabolism ArgF is involved in the biosynthesis of L-arginine, overview Corynebacterium glutamicum