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Literature summary for 2.1.3.3 extracted from

  • Diaz-Munoz, M.; Hernandez-Munoz, R.
    Molecular and biochemical features of the mitochondrial enzyme ornithine transcarbamylase: a possible new role as a signaling factor (2010), Curr. Med. Chem., 17, 2253-2260.
    View publication on PubMed
Search for more literature for 2.1.3.3

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial matrix
-
 Homo sapiens 5759
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38000
-
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
carbamoyl phosphate + L-ornithine = phosphate + L-citrulline ping-pong reaction mechanism Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell
-
 Homo sapiens
-
intestine
-
 Homo sapiens
-
liver high content Homo sapiens
-

Subunits

Subunits Comment Organism
trimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
ornithine transcarbamoylase
-
 Homo sapiens
OTC
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction inborn deficiency of OTC causes mainly urea cycle-related disorders and leads to hyperammonemic states that may become lethal. Some states of hepatotoxicity are associated woth hepatocyte disruption and release of OTC into the bloodstream Homo sapiens
physiological function OTC is involved in the metabolic transformation of arginine and proline and participates in the urea cycle. OTC is regulated by glucocorticoids and other transcriptional factors, such as C/EFP and HNF-4. OTC is released into the blood stream from liver in case of liver regeneration cell proliferation, extracellular might play a role as signaling molecule Homo sapiens