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Literature summary for 2.1.4.1 extracted from

  • Dubach, U.C.
    Transamidinase (1974), Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. ), 1, 740-743.
No PubMed abstract available
Search for more literature for 2.1.4.1

Application

Application Comment Organism
medicine presence of the enzyme in serum or urine may prove useful in development of kidney disease diagnosis, hyperornithinemia, an autosomal recessive disease caused by decreased enzyme activity, enzyme activity is also dimished in thyrotoxicosis and myotonic muscular dystrophy Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
p-chloromercuribenzoate
-
 Rattus norvegicus
p-chloromercuribenzoate
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine + glycine Homo sapiens
-
 L-ornithine + guanidinoacetate
-
 r
L-arginine + glycine Rattus norvegicus
-
 L-ornithine + guanidinoacetate
-
 r
L-arginine + glycine Sus scrofa
-
 L-ornithine + guanidinoacetate
-
 r
L-ornithine + guanidinoacetate Sus scrofa
-
 L-arginine + glycine
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-
Rattus norvegicus
-
 rat
-
Sus scrofa
-
 pig, porcine, hog
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Homo sapiens
-
blood
-
 Sus scrofa
-
brain
-
 Homo sapiens
-
brain
-
 Rattus norvegicus
-
brain
-
 Sus scrofa
-
erythrocyte
-
 Sus scrofa
-
heart
-
 Sus scrofa
-
kidney
-
 Sus scrofa
-
lung
-
 Sus scrofa
-
muscle
-
 Sus scrofa
-
pancreas
-
 Sus scrofa
-
spleen
-
 Homo sapiens
-
spleen
-
 Rattus norvegicus
-
spleen
-
 Sus scrofa
-
testis
-
 Sus scrofa
-
thymus
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
canavanine + canaline
-
 Homo sapiens canaline + canavanine
-
 ?
canavanine + canaline
-
 Rattus norvegicus canaline + canavanine
-
 ?
canavanine + canaline
-
 Sus scrofa canaline + canavanine
-
 ?
canavanine + glycine
-
 Homo sapiens guanidinoacetate + canaline
-
 r
canavanine + glycine
-
 Rattus norvegicus guanidinoacetate + canaline
-
 r
canavanine + glycine
-
 Sus scrofa guanidinoacetate + canaline
-
 r
canavanine + ornithine
-
 Homo sapiens arginine + canaline
-
 r
canavanine + ornithine
-
 Rattus norvegicus arginine + canaline
-
 r
canavanine + ornithine
-
 Sus scrofa arginine + canaline
-
 r
guanidinoacetate + hydroxylamine
-
 Homo sapiens hydroxyguanidine + glycine
-
 ?
guanidinoacetate + hydroxylamine
-
 Rattus norvegicus hydroxyguanidine + glycine
-
 ?
guanidinoacetate + hydroxylamine
-
 Sus scrofa hydroxyguanidine + glycine
-
 ?
homoarginine + glycine
-
 Homo sapiens homoornithine + guanidinoacetate
-
 r
homoarginine + glycine
-
 Rattus norvegicus homoornithine + guanidinoacetate
-
 r
homoarginine + glycine
-
 Sus scrofa homoornithine + guanidinoacetate
-
 r
L-arginine + glycine
-
 Homo sapiens L-ornithine + guanidinoacetate
-
 r
L-arginine + glycine
-
 Rattus norvegicus L-ornithine + guanidinoacetate
-
 r
L-arginine + glycine
-
 Sus scrofa L-ornithine + guanidinoacetate
-
 r
L-ornithine + guanidinoacetate
-
 Sus scrofa L-arginine + glycine
-
 r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 7.5
-
 Sus scrofa