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Literature summary for 2.2.1.5 extracted from

  • Maksymiuk, C.; Ioerger, T.; Balakrishnan, A.; Bryk, R.; Rhee, K.; Sacchettini, J.; Nathan, C.
    Comparison of transposon and deletion mutants in Mycobacterium tuberculosis The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase (2015), Tuberculosis, 95, 689-694 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.2.1.5

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-oxoglutarate + glyoxylate Mycobacterium tuberculosis
-
 2-hydroxy-3-oxoadipate + CO2
-
 ?
2-oxoglutarate + glyoxylate Mycobacterium tuberculosis CDC1551
-
 2-hydroxy-3-oxoadipate + CO2
-
 ?
2-oxoglutarate + glyoxylate Mycobacterium tuberculosis H37Rv
-
 2-hydroxy-3-oxoadipate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis CDC1551
-
-
-
Mycobacterium tuberculosis H37Rv
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + glyoxylate
-
 Mycobacterium tuberculosis 2-hydroxy-3-oxoadipate + CO2
-
 ?
2-oxoglutarate + glyoxylate
-
 Mycobacterium tuberculosis CDC1551 2-hydroxy-3-oxoadipate + CO2
-
 ?
2-oxoglutarate + glyoxylate
-
 Mycobacterium tuberculosis H37Rv 2-hydroxy-3-oxoadipate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
HOAS
-
 Mycobacterium tuberculosis
Rv1248c
-
 Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate dependent on Mycobacterium tuberculosis

General Information

General Information Comment Organism
malfunction enzyme deletion severely attenuates Mycobacterium tuberculosis in vivo Mycobacterium tuberculosis