Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ile | mild inhibition of isoenzyme I and III | Escherichia coli | |
Ile | inhibition of isoenzyme I, no inhibition of isoenzyme II | Salmonella enterica subsp. enterica serovar Typhimurium | |
Leu | no inhibition of isoenzyme I and III | Escherichia coli | |
Leu | inhibition of isoenzyme I, no inhibition of isoenzyme II | Salmonella enterica subsp. enterica serovar Typhimurium | |
Val | isoenzymes I and II are inhibited, isoenzyme II is not inhibited | Escherichia coli | |
Val | isoenzymes I and II are inhibited, isoenzyme II is not inhibited | Salmonella enterica subsp. enterica serovar Typhimurium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyruvate | Salmonella enterica subsp. enterica serovar Typhimurium | isoenzyme II is regulated by Leu, Ile and Val | ? | - |
? | |
pyruvate | Escherichia coli | isoenzyme II is regulated by Leu, Ile and Val | ? | - |
? | |
pyruvate | Salmonella enterica subsp. enterica serovar Typhimurium | isoenzyme II is regulated by Leu | ? | - |
? | |
pyruvate | Escherichia coli | isoenzyme II is regulated by Leu | ? | - |
? | |
pyruvate | Salmonella enterica subsp. enterica serovar Typhimurium | first enzyme unique to biosynthesis of the branched chain amino acids Val, Leu, and Ile | ? | - |
? | |
pyruvate | Escherichia coli | first enzyme unique to biosynthesis of the branched chain amino acids Val, Leu, and Ile | ? | - |
? | |
pyruvate | Salmonella enterica subsp. enterica serovar Typhimurium | isoenzyme I is regulated by Leu and Val | ? | - |
? | |
pyruvate | Escherichia coli | isoenzyme I is regulated by Leu and Val | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
K-12 | - |
Escherichia coli | - |
3 isoenzymes: I, II, and III | - |
Escherichia coli | - |
isoenzyme I and III are expressed in wild type cells, isoenzyme II is cryptic | - |
Salmonella enterica subsp. enterica serovar Typhimurium | - |
3 isoenzymes: I, II, and III | - |
Salmonella enterica subsp. enterica serovar Typhimurium | - |
isoenzyme I and II are expressed in wild type cells, isoenzyme III is cryptic | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyruvate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 2-acetolactate + CO2 | - |
? | |
pyruvate | - |
Escherichia coli | 2-acetolactate + CO2 | - |
? | |
pyruvate | isoenzyme II is regulated by Leu, Ile and Val | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
pyruvate | isoenzyme II is regulated by Leu, Ile and Val | Escherichia coli | ? | - |
? | |
pyruvate | isoenzyme II is regulated by Leu | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
pyruvate | isoenzyme II is regulated by Leu | Escherichia coli | ? | - |
? | |
pyruvate | first enzyme unique to biosynthesis of the branched chain amino acids Val, Leu, and Ile | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
pyruvate | first enzyme unique to biosynthesis of the branched chain amino acids Val, Leu, and Ile | Escherichia coli | ? | - |
? | |
pyruvate | isoenzyme I is regulated by Leu and Val | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
pyruvate | isoenzyme I is regulated by Leu and Val | Escherichia coli | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
isoenzyme I | Salmonella enterica subsp. enterica serovar Typhimurium |
7 | - |
isoenzyme I | Escherichia coli |
8 | - |
isoenzyme II | Salmonella enterica subsp. enterica serovar Typhimurium |
8 | - |
isoenzyme II | Escherichia coli |
9 | - |
isoenzyme III | Salmonella enterica subsp. enterica serovar Typhimurium |
9 | - |
isoenzyme III | Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | partial requirement for isoenzyme III | Salmonella enterica subsp. enterica serovar Typhimurium | |
FAD | absolutly required for isoenzyme I and II, no requirement for isoenzyme III | Escherichia coli |