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Literature summary for 2.2.1.6 extracted from
- Studies in valine biosynthesis. X. The acetolactate synthase from Rhodopseudomonas spheroides (1977), Microbios, 20, 7-14.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Val | competitive | Cereibacter sphaeroides |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 4.5 | - |
pyruvate | - |
Cereibacter sphaeroides | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Cereibacter sphaeroides | |
| Mg2+ | Km: 1.01 mM | Cereibacter sphaeroides | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyruvate | Cereibacter sphaeroides | first enzyme unique to biosynthesis of the branched chain amino acids Val, Leu, and Ile | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cereibacter sphaeroides | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyruvate | - |
Cereibacter sphaeroides | 2-acetolactate + CO2 | - |
? | |
| pyruvate | first enzyme unique to biosynthesis of the branched chain amino acids Val, Leu, and Ile | Cereibacter sphaeroides | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | 7.4 | - |
Cereibacter sphaeroides |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | required | Cereibacter sphaeroides | |
| thiamine diphosphate | - |
Cereibacter sphaeroides | |
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Release 2023.1 (January 2023)
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