Protein Variants | Comment | Organism |
---|---|---|
R478A | the mutant shows reduced affinity for D-glyceraldehyde 3-phosphate compared to the wild type enzyme | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)-3-(4-hydroxyphenyl)propanoate | - |
Escherichia coli | |
(2R)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)-3-phenylpropanoate | most potent selective inhibitor | Escherichia coli | |
(2R)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)propanoate | - |
Escherichia coli | |
(2S)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)-3-(4-hydroxyphenyl)propanoate | - |
Escherichia coli | |
(2S)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)-3-phenylpropanoate | - |
Escherichia coli | |
(2S)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)propanoate | - |
Escherichia coli | |
2-(1-benzyl-1H-1,2,3-triazol-4-yl)ethyl acetylphosphonate | - |
Escherichia coli | |
2-(1-cyclohexyl-1H-1,2,3-triazol-4-yl)ethyl acetylphosphonate | - |
Escherichia coli | |
2-(1-pentyl-1H-1,2,3-triazol-4-yl)ethyl acetylphosphonate | - |
Escherichia coli | |
2-(1-[(2S)-1-[methyl(4-methylbenzene-1-sulfonyl)amino]-1-oxo-3-phenylpropan-2-yl]-1H-1,2,3-triazol-4-yl)ethyl acetylphosphonate | - |
Escherichia coli | |
2-(1-[2-[methyl(methylsulfonyl)amino]-2-oxoethyl]-1H-1,2,3-triazol-4-yl)ethyl acetylphosphonate | - |
Escherichia coli | |
2-[1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | - |
Escherichia coli | |
2-[1-(2-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | - |
Escherichia coli | |
2-[1-(2-methoxy-2-oxoethyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | - |
Escherichia coli | |
2-[1-(2-nitrobenzyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | - |
Escherichia coli | |
2-[1-(2-phenylethyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | - |
Escherichia coli | |
2-[1-(2-[methyl[(4-methylphenyl)sulfonyl]amino]-2-oxoethyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | - |
Escherichia coli | |
2-[1-(3-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | - |
Escherichia coli | |
2-[1-(4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | - |
Escherichia coli | |
2-[1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | - |
Escherichia coli | |
2-[1-(carboxymethyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | - |
Escherichia coli | |
2-[1-(prop-2-en-1-yl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | - |
Escherichia coli | |
2-[1-[4-(methoxycarbonyl)benzyl]-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | - |
Escherichia coli | |
butylacetylphosphonate | - |
Escherichia coli | |
lithium but-3-yn-1-yl acetylphosphonate | - |
Escherichia coli | |
Methylacetylphosphonate | - |
Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.042 | - |
D-glyceraldehyde 3-phosphate | wild type enzyme, at pH 8.0 and 37°C | Escherichia coli | |
2.3 | - |
D-glyceraldehyde 3-phosphate | mutant enzyme R478A, at pH 8.0 and 37°C | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyruvate + D-glyceraldehyde 3-phosphate | Escherichia coli | - |
1-deoxy-D-xylulose 5-phosphate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyruvate + D-glyceraldehyde 3-phosphate | - |
Escherichia coli | 1-deoxy-D-xylulose 5-phosphate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DXP synthase | - |
Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
thiamine diphosphate | - |
Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00009 | - |
(2R)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)-3-phenylpropanoate | at pH 8.0 and 37°C | Escherichia coli | |
0.00011 | - |
2-[1-(2-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
0.00032 | - |
2-[1-(3-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
0.00033 | - |
(2R)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)-3-(4-hydroxyphenyl)propanoate | at pH 8.0 and 37°C | Escherichia coli | |
0.00044 | - |
2-(1-cyclohexyl-1H-1,2,3-triazol-4-yl)ethyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
0.00047 | - |
lithium but-3-yn-1-yl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
0.00047 | - |
2-[1-(2-[methyl[(4-methylphenyl)sulfonyl]amino]-2-oxoethyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
0.00052 | - |
2-(1-[2-[methyl(methylsulfonyl)amino]-2-oxoethyl]-1H-1,2,3-triazol-4-yl)ethyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
0.00083 | - |
2-(1-[(2S)-1-[methyl(4-methylbenzene-1-sulfonyl)amino]-1-oxo-3-phenylpropan-2-yl]-1H-1,2,3-triazol-4-yl)ethyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
0.00084 | - |
2-[1-(carboxymethyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
0.001 | - |
2-[1-(2-hydroxyethyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
0.001 | - |
(2S)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)-3-(4-hydroxyphenyl)propanoate | at pH 8.0 and 37°C | Escherichia coli | |
0.0013 | - |
2-[1-(2-methoxy-2-oxoethyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
0.0013 | - |
(2S)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)propanoate | at pH 8.0 and 37°C | Escherichia coli | |
0.0021 | - |
(2S)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)-3-phenylpropanoate | at pH 8.0 and 37°C | Escherichia coli | |
0.0026 | - |
butylacetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
0.0027 | - |
2-[1-(4-nitrobenzyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
0.0029 | - |
(2R)-2-(4-[2-[(acetylphosphinato)oxy]ethyl]-1H-1,2,3-triazol-1-yl)propanoate | at pH 8.0 and 37°C | Escherichia coli | |
0.003 | - |
2-(1-pentyl-1H-1,2,3-triazol-4-yl)ethyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
0.0054 | - |
2-[1-(2-nitrobenzyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
0.006 | - |
2-[1-(4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
0.006 | - |
2-[1-(prop-2-en-1-yl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
0.008 | - |
2-(1-benzyl-1H-1,2,3-triazol-4-yl)ethyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
0.008 | - |
2-[1-(2-phenylethyl)-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
0.008 | - |
2-[1-[4-(methoxycarbonyl)benzyl]-1H-1,2,3-triazol-4-yl]ethyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0018 | - |
wild type enzyme, at pH 8.0 and 37°C | Escherichia coli | Methylacetylphosphonate | |
0.005 | - |
mutant enzyme R478A, at pH 8.0 and 37°C | Escherichia coli | Methylacetylphosphonate |