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Literature summary for 2.3.1.1 extracted from

  • Caldovic, L.; Lopez, G.Y.; Haskins, N.; Panglao, M.; Shi, D.; Morizono, H.; Tuchman, M.
    Biochemical properties of recombinant human and mouse N-acetylglutamate synthase (2006), Mol. Genet. Metab., 87, 226-232.
    View publication on PubMed
Search for more literature for 2.3.1.1

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mus musculus
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Arg activates Homo sapiens
Arg activates Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.94
-
 acetyl-CoA mature enzyme without affinity tag Homo sapiens
0.94
-
 acetyl-CoA mature enzyme without affinity tag, in presence of 1 mM Arg Homo sapiens
1.01
-
 acetyl-CoA mature enzyme with polyhistidine tag and thrombin protease recognition sequence Mus musculus
2.5
-
 L-glutamate mature enzyme without affinity tag Homo sapiens
2.5
-
 L-glutamate mature enzyme without affinity tag, in presence of 1 mM Arg Homo sapiens
2.91
-
 L-glutamate mature enzyme with polyhistidine tag and thrombin protease recognition sequence Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N159 recombinant
-
Mus musculus Q8R4H7 recombinant
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + L-glutamate
-
 Mus musculus CoA + N-acetyl-L-glutamate
-
 ?
acetyl-CoA + L-glutamate
-
 Homo sapiens CoA + N-acetyl-L-glutamate
-
 ?