Application | Comment | Organism |
---|---|---|
agriculture | reduction of content and improvement of biomass saccharification can be achieved by engineering transgenic lines that overproduce non-canonical substrates 3-hydroxybenzoate, gentisate, 2,3-dihydroxybenzoate, protocatechuate, 3-aminobenzoate, 3-hydroxyanthranilate, 5-hydroxyanthranilate, catechol or hydroquinone | Arabidopsis thaliana |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Panicum virgatum |
Crystallization (Comment) | Organism |
---|---|
in complex with CoA and 4-coumaroyl-shikimate. The 4-coumaroyl-shikimate contacts the enzyme via the phenolic group and carbonyl group of the 4-coumaroyl portion. The shikimate portion contacts the enzyme through both the carboxyl and hydroxyl groups. In the protocatechuate ternary complex, protocatechuate binds in a very similar manner to shikimate, with the carboxyl group making a tight salt bridge with Arg369, and the C3 hydroxyl group interacting with the nitrogen NE2 of His163 | Panicum virgatum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,3-Dihydroxybenzoate | 0.8 mM, about 50% inhibition | Panicum virgatum | |
3-aminobenzoate | 0.8 mM, about 45% inhibition | Panicum virgatum | |
3-Hydroxyanthranilate | 0.8 mM, about 45% inhibition | Panicum virgatum | |
protocatechuate | 0.8 mM, about 40% inhibition | Panicum virgatum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.699 | - |
shikimate | pH 7.5, 30°C | Panicum virgatum | |
0.83 | - |
3-Hydroxyanthranilate | pH 7.5, 30°C | Panicum virgatum | |
1.48 | - |
3,4-dihydroxybenzoate | pH 7.5, 30°C | Panicum virgatum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | Q9FI78 | - |
- |
Panicum virgatum | R9RYW2 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-coumaroyl-CoA + 2,3-dihydroxybenzoate | - |
Arabidopsis thaliana | CoA + 3-O-(4-coumaroyl)oxy-2-hydroxybenzoate | - |
? | |
4-coumaroyl-CoA + 2,3-dihydroxybenzoate | low affinity substrate | Panicum virgatum | CoA + 3-O-(4-coumaroyl)oxy-2-hydroxybenzoate | - |
? | |
4-coumaroyl-CoA + 3,4-dihydroxybenzoate | i.e. protocatechuate | Panicum virgatum | CoA + 3-O-(4-coumaroyl)oxy-4-hydroxybenzoate | - |
? | |
4-coumaroyl-CoA + 3,4-dihydroxybenzoate | i.e. protocatechuate | Arabidopsis thaliana | CoA + 3-O-(4-coumaroyl)oxy-4-hydroxybenzoate | - |
? | |
4-coumaroyl-CoA + 3-aminobenzoate | - |
Arabidopsis thaliana | CoA + 3-N-(4-coumaroyl)aminobenzoate | - |
? | |
4-coumaroyl-CoA + 3-aminobenzoate | low affinity substrate | Panicum virgatum | CoA + 3-N-(4-coumaroyl)aminobenzoate | - |
? | |
4-coumaroyl-CoA + 3-hydroxyanthranilate | - |
Panicum virgatum | CoA + 3-(4-coumaroyl)oxyanthranilate | - |
? | |
4-coumaroyl-CoA + 3-hydroxyanthranilate | - |
Arabidopsis thaliana | CoA + 3-(4-coumaroyl)oxyanthranilate | - |
? | |
4-coumaroyl-CoA + 3-hydroxybenzoate | - |
Arabidopsis thaliana | CoA + 3-O-(4-coumaroyl)oxy-benzoate | - |
? | |
4-coumaroyl-CoA + 3-hydroxybenzoate | low affinity substrate | Panicum virgatum | CoA + 3-O-(4-coumaroyl)oxy-benzoate | - |
? | |
4-coumaroyl-CoA + 5-hydroxyanthranilate | - |
Arabidopsis thaliana | CoA + 5-(4-coumaroyl)oxyanthranilate | - |
? | |
4-coumaroyl-CoA + 5-hydroxyanthranilate | low affinity substrate | Panicum virgatum | CoA + 5-(4-coumaroyl)oxyanthranilate | - |
? | |
4-coumaroyl-CoA + catechol | low affinity substrate | Panicum virgatum | CoA + 1-(4-coumaroyl)catechol | - |
? | |
4-coumaroyl-CoA + catechol | - |
Arabidopsis thaliana | CoA + 1-O-(4-coumaroyl)catechol | - |
? | |
4-coumaroyl-CoA + gentisate | - |
Arabidopsis thaliana | CoA + 5-O-(4-coumaroyl)gentisate | - |
? | |
4-coumaroyl-CoA + gentisate | low affinity substrate | Panicum virgatum | CoA + 5-O-(4-coumaroyl)gentisate | - |
? | |
4-coumaroyl-CoA + hydroquinone | low affinity substrate | Panicum virgatum | CoA + 1-(4-coumaroyl)hydroquinone | - |
? | |
4-coumaroyl-CoA + hydroquinone | - |
Arabidopsis thaliana | CoA + 1-O-(4-coumaroyl)hydroquinone | - |
? | |
4-coumaroyl-CoA + shikimate | - |
Panicum virgatum | CoA + 5-O-(4-coumaroyl)shikimate | - |
? | |
4-coumaroyl-CoA + shikimate | - |
Arabidopsis thaliana | CoA + 5-O-(4-coumaroyl)shikimate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HCT2a | - |
Panicum virgatum |