Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.137 extracted from

  • Nic A'Bhaird, N.; Ramsay, R.R.
    Malonyl-CoA inhibition of peroxisomal carnitine octanoyltransferase (1992), Biochem. J., 286, 637-640.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
malonyl-CoA inhibits the purified enzyme, inhibition is affected by buffer, pH, substrate and presence or absence of bovine serum albumin Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00024
-
decanoyl-CoA pH 6.8 Rattus norvegicus
0.00034
-
decanoyl-CoA pH 7.4 Rattus norvegicus
0.00046
-
palmitoyl-CoA peroxisomal COT Rattus norvegicus
0.00047
-
palmitoyl-CoA pH 6.8 Rattus norvegicus
0.0006
-
palmitoyl-CoA purified COT, pH 7.4 Rattus norvegicus
0.102
-
L-carnitine pH 7.4 Rattus norvegicus
0.227
-
L-carnitine pH 6.8 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-
peroxisome
-
Rattus norvegicus 5777
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + L-carnitine Rattus norvegicus
-
acyl-L-carnitine + CoA
-
r
acyl-L-carnitine + CoA Rattus norvegicus
-
acyl-CoA + L-carnitine
-
r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
rat
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + L-carnitine
-
Rattus norvegicus acyl-L-carnitine + CoA
-
r
acyl-L-carnitine + CoA
-
Rattus norvegicus acyl-CoA + L-carnitine
-
r
palmitoyl-CoA + L-carnitine
-
Rattus norvegicus L-palmitoyl-L-carnitine + CoA
-
r
palmitoyl-L-carnitine + CoA
-
Rattus norvegicus palmitoyl-CoA + L-carnitine
-
r

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0035
-
malonyl-CoA pH 6.8 Rattus norvegicus
0.0064
-
malonyl-CoA peroxisomal COT Rattus norvegicus
0.106
-
malonyl-CoA pH 7.4 Rattus norvegicus