Application | Comment | Organism |
---|---|---|
medicine | lack of GPAT1 activity affects both innate and adaptive immune mechanisms | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Synonyms | Comment | Organism |
---|---|---|
glycerol-3-phosphate acyltransferase 1 | - |
Mus musculus |
GPAT1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | livers and hearts from mice deficient in GPAT1 (Gpat1 -/-) have a decreased content of glycerolipid intermediates and triacylglycerol, an altered composition of liver phospholipids, and elevated markers of oxidative stress. Compared with control C57BL/6 mice, infection of Gpat1 -/- mice with coxsackievirus B3 results in higher mortality, an 50% increase in heart pathology, a significant increase in liver viral titers, and a 100fold increase in heart viral titers. Heart mRNA levels for proinflammatory cytokines TNF-alpha, IL-6, and IL-1B are increased in the Gpat1-/- mice. Loss of Gpat1 also results in dysregulation of specific immune cells | Mus musculus |