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Literature summary for 2.3.1.165 extracted from

  • Dimroth, P.; Ringelmann, E.; Lynen, F.
    6-Methylsalicylic acid synthetase from Penicillium patulum. Some catalytic properties of the enzyme and its relation to fatty acid synthetase (1976), Eur. J. Biochem., 68, 591-596.
    View publication on PubMed
Search for more literature for 2.3.1.165

General Stability

General Stability Organism
activity is lost upon storage Penicillium griseofulvum

Inhibitors

Inhibitors Comment Organism Structure
iodoacetamide 0.5 mM, complete inactivation of synthetase activity after 15 min at 0°C, enzyme is then able to decarboxlate malonyl-CoA Penicillium griseofulvum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + malonyl-CoA + NADPH Penicillium griseofulvum
-
 6-methylsalicylate + CoA + CO2 + NADP+
-
 ?
acetyl-CoA + malonyl-CoA + NADPH Penicillium griseofulvum NRRL 2159A
-
 6-methylsalicylate + CoA + CO2 + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Penicillium griseofulvum
-
 NRRL 2159A
-
Penicillium griseofulvum NRRL 2159A
-
 NRRL 2159A
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + malonyl-CoA + NADPH
-
 Penicillium griseofulvum 6-methylsalicylate + CoA + CO2 + NADP+
-
 ?
acetyl-CoA + malonyl-CoA + NADPH
-
 Penicillium griseofulvum NRRL 2159A 6-methylsalicylate + CoA + CO2 + NADP+
-
 ?
acetyl-CoA + pantetheine
-
 Penicillium griseofulvum acetyl pantetheine + CoA
-
 ?
acetyl-CoA + pantetheine
-
 Penicillium griseofulvum NRRL 2159A acetyl pantetheine + CoA
-
 ?
propionyl-CoA + malonyl-CoA + NADPH
-
 Penicillium griseofulvum 6-ethylsalicylate + CoA + CO2 + NADP+
-
 ?
propionyl-CoA + malonyl-CoA + NADPH
-
 Penicillium griseofulvum NRRL 2159A 6-ethylsalicylate + CoA + CO2 + NADP+
-
 ?
propionyl-CoA + pantetheine 13 times slower rate compared to acetyl-CoA Penicillium griseofulvum propionyl pantetheine + CoA
-
 ?
propionyl-CoA + pantetheine 13 times slower rate compared to acetyl-CoA Penicillium griseofulvum NRRL 2159A propionyl pantetheine + CoA
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Penicillium griseofulvum