Literature summary for 2.3.1.169 extracted from

Tan, X.; Loke, H.K.; Fitch, S.; Lindahl, P.A.
The tunnel of acetyl-coenzyme A synthase/carbon monoxide dehydrogenase regulates delivery of CO to the active site (2005), J. Am. Chem. Soc., 127, 5833-5839.

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Protein Variants

Protein Variants	Comment	Organism
A110C	absence of strong cooperative inhibition of CO which characterizes wild-type enzyme	Moorella thermoacetica
A222L	the bifunctional mutant enzyme is not able to synthesize acetyl-CoA using CO2 as substrate	Moorella thermoacetica
A265M	absence of strong cooperative inhibition of CO which characterizes wild-type enzyme	Moorella thermoacetica

Inhibitors

Inhibitors	Comment	Organism	Structure
CO	the complete alpha2beta2 enzyme exhibits strong cooperative inhibition, isolated alpha is weakly inhibited, apparently by a single CO with Ki = 1.5 mM. Absence of strong cooperative inhibition of CO in mutant enzymes A265M and AA110C	Moorella thermoacetica

Organism

Organism	UniProt	Comment	Textmining
Moorella thermoacetica	-	-	-

Synonyms

Synonyms	Comment	Organism
acetyl-coenzyme A synthase/carbon monoxide dehydrogenase	-	Moorella thermoacetica
ACS/CODH	-	Moorella thermoacetica

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
1.5	-	CO	the complete alpha2beta2 enzyme exhibits strong cooperative inhibition, isolated alpha is weakly inhibited, apparently by a single CO with Ki = 1.5 mM	Moorella thermoacetica

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Release 2023.1 (January 2023)