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Literature summary for 2.3.1.180 extracted from

  • Li, Y.; Luo, Y.; Hu, Y.; Zhu, D.D.; Zhang, S.; Liu, Z.J.; Gong, H.B.; Zhu, H.L.
    Design, synthesis and antimicrobial activities of nitroimidazole derivatives containing 1,3,4-oxadiazole scaffold as FabH inhibitors (2012), Bioorg. Med. Chem., 20, 4316-4322.
    View publication on PubMed
Search for more literature for 2.3.1.180

Cloned(Commentary)

Cloned (Comment) Organism
His-tagged protein expressed in Escherichia coli BL21(DE3) Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
2-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-5-(2-methylbenzyl)-1,3,4-oxadiazole
-
 Escherichia coli
2-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol
-
 Escherichia coli
2-(2-methoxyphenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
-
 Escherichia coli
2-(3-bromophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
-
 Escherichia coli
2-(3-methoxyphenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
-
 Escherichia coli
2-(4-bromophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
-
 Escherichia coli
2-(4-chlorophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
-
 Escherichia coli
2-(4-fluorophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
-
 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
immobilized metal ion affinity chromatography (Ni2+) Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
malonyl-ACP + acetyl-CoA
-
 Escherichia coli CO2 + CoA + acetoacetyl-ACP
-
 ?

Synonyms

Synonyms Comment Organism
beta-ketoacyl-acyl carrier protein synthase III
-
 Escherichia coli
FabH
-
 Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0043
-
 pH 7.0, temperature not specified in the publication Escherichia coli 2-(2-methoxyphenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
0.0051
-
 pH 7.0, temperature not specified in the publication Escherichia coli 2-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-5-(2-methylbenzyl)-1,3,4-oxadiazole
0.0094
-
 pH 7.0, temperature not specified in the publication Escherichia coli 2-(3-methoxyphenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
0.0169
-
 pH 7.0, temperature not specified in the publication Escherichia coli 2-(3-bromophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
0.0186
-
 pH 7.0, temperature not specified in the publication Escherichia coli 2-(4-fluorophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
0.0283
-
 pH 7.0, temperature not specified in the publication Escherichia coli 2-(4-chlorophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole
0.0405
-
 pH 7.0, temperature not specified in the publication Escherichia coli 2-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol
0.0438
-
 pH 7.0, temperature not specified in the publication Escherichia coli 2-(4-bromophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole