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Literature summary for 2.3.1.211 extracted from

  • Ramirez-Ahumada, M.d.e.l.C.; Timmermann, B.N.; Gang, D.R.
    Biosynthesis of curcuminoids and gingerols in turmeric (Curcuma longa) and ginger (Zingiber officinale): identification of curcuminoid synthase and hydroxycinnamoyl-CoA thioesterases (2006), Phytochemistry, 67, 2017-2029.
    View publication on PubMed
Search for more literature for 2.3.1.211

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 4-coumaroyl-CoA + malonyl-CoA + H2O Curcuma longa
-
 3 CoA + bisdemethoxycurcumin + 2 CO2
-
 ?
additional information Curcuma longa the curcuminoid synthase might also use feruloyl-CoA as substrate, via demethoxycurcumin, to curcumin, possible pathway overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Curcuma longa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf highest activity Curcuma longa
-
rhizome
-
 Curcuma longa
-
shoot
-
 Curcuma longa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 4-coumaroyl-CoA + malonyl-CoA + H2O
-
 Curcuma longa 3 CoA + bisdemethoxycurcumin + 2 CO2
-
 ?
additional information the curcuminoid synthase might also use feruloyl-CoA as substrate, via demethoxycurcumin, to curcumin, possible pathway overview Curcuma longa ?
-
 ?
additional information curcuminoid synthase activity shows a requirement for both 4-coumaroyl-CoA and feruloyl-CoA to be present in the activity assay in order for any product to be observed Curcuma longa ?
-
 ?

Synonyms

Synonyms Comment Organism
curcuminoid synthase
-
 Curcuma longa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
28
-
 assay at Curcuma longa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Curcuma longa

General Information

General Information Comment Organism
metabolism the enzyme is involved in the phenylpropanoid pathway. Thioesterase activities in Curcuma longa that cleave phenylpropanoid pathway CoA esters, are present at high levels in all tissues and may shunt phenylpropanoid pathway intermediates away from the production of curcuminoids and gingerols, thereby potentially playing a regulatory role in the biosynthesis of these compounds Curcuma longa