Literature summary for 2.3.1.22 extracted from

McFie, P.J.; Izzard, S.; Vu, H.; Jin, Y.; Beauchamp, E.; Berthiaume, L.G.; Stone, S.J.
Membrane topology of human monoacylglycerol acyltransferase-2 and identification of regions important for its localization to the endoplasmic reticulum (2016), Biochim. Biophys. Acta, 1861, 1192-1204 .

Search for more literature for 2.3.1.22

Cloned(Commentary)

Cloned (Comment)	Organism
expression in HEK-293T cell	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
C122A	about 20-30% of wild-type activity	Homo sapiens
C313A	about 20-30% of wild-type activity	Homo sapiens
C334A	located at the extreme C-terminus, about 200% of wild-type activity	Homo sapiens
C34A	about 20-30% of wild-type activity	Homo sapiens
DELTAC76	about 20-30% of wild-type activity	Homo sapiens
additional information	a mutant lacking all five cysteine residues is devoid of monoacylglycerol acyltransferase activity	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
5,5'-dithiobis-(2-nitrobenzoic acid)	-	Homo sapiens
N-ethylmaleimide	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	integral membrane protein, the C-terminus is exposed to the cytosol, while the N-terminus is partially buried in the ER membrane. Domains that are important for catalysis face the cytosol. Both transmembrane domains of MGAT2 are important for its ER localization, and MGAT2 is present in mitochondrial-associated membranes	Homo sapiens	5783	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q3SYC2	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[N-[(7-nitro-2-1,3-benzoxadiazol-4-yl)-methyl]amino]palmitoyl-CoA + 2-oleoylglycerol	-	Homo sapiens	CoA + 1-[N-[(7-nitro-2-1,3-benzoxadiazol-4-yl)-methyl]amino]palmitoyl-2-oleoylglycerol	-	-

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Release 2023.1 (January 2023)