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BRENDA support

Literature summary for 2.3.1.225 extracted from

  • Li, Y.; Hu, J.; Hoefer, K.; Wong, A.M.; Cooper, J.D.; Birnbaum, S.G.; Hammer, R.E.; Hofmann, S.L.
    DHHC5 interacts with PDZ domain 3 of post-synaptic density-95 (PSD-95) protein and plays a role in learning and memory (2010), J. Biol. Chem., 285, 13022-13031.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane localized to synaptic membranes Mus musculus 16020
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Organism

Organism UniProt Comment Textmining
Mus musculus Q8VDZ4
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Source Tissue

Source Tissue Comment Organism Textmining
hippocampus expression in the hippocampal subfield CA3 and the dentate gyrus Mus musculus
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Synonyms

Synonyms Comment Organism
DHHC5
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Mus musculus

General Information

General Information Comment Organism
physiological function mice homozygous for DHHC5, are born at half the expected rate, and survivors show a marked deficit in contextual fear conditioning, an indicator of defective hippocampal-dependent learning. DHHC5 is highly enriched in a post-synaptic density preparation and co-immunoprecipitates with post-synaptic density protein PSD-95, an interaction that is mediated through binding of the carboxyl terminus of DHHC5 and the PDZ3 domain of PSD-95 Mus musculus