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Literature summary for 2.3.1.225 extracted from

  • Hemsley, P. A.; Kemp, A. C.; Grierson, C. S.
    The TIP GROWTH DEFECTIVE1 S-acyl transferase regulates plant cell growth in Arabidopsis (2005), Plant Cell, 17, 2554-2563.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene TIP, location on chromosome 2, DNA and amino acid sequence determination and analysis, expression of TIP1 complements Saccharomyces cerevisiae cells deficient in the AKR1p S-acyl transferase Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information generation of tip1-1, tip1-2, and tip1-3 mutants, overview. Several stable transformants carrying Pro35S:TIP1 have significantly longer root hairs than does the wild-type, phenotype, overview Arabidopsis thaliana

Inhibitors

Inhibitors Comment Organism Structure
2-Bromopalmitate
-
Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + [protein]-L-cysteine Arabidopsis thaliana
-
[protein]-S-palmitoyl-L-cysteine + CoA
-
r

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q52T38
-
-

Source Tissue

Source Tissue Comment Organism Textmining
flower
-
Arabidopsis thaliana
-
inflorescence
-
Arabidopsis thaliana
-
leaf
-
Arabidopsis thaliana
-
root
-
Arabidopsis thaliana
-
stem
-
Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + [protein]-L-cysteine
-
Arabidopsis thaliana [protein]-S-palmitoyl-L-cysteine + CoA
-
r

Synonyms

Synonyms Comment Organism
Pat
-
Arabidopsis thaliana

General Information

General Information Comment Organism
evolution TIP1 is a plant member of an evolutionarily conserved group of proteins that contains six ankyrin repeats and a DHHC-CRD and that are predicted to be integral membrane proteins Arabidopsis thaliana
malfunction the TIP GROWTH DEFECTIVE1 mutation affects cell growth throughout the plant and has a particularly strong effect on root hair growth. Inhibition of acylation in wild-type Arabidopsis thaliana roots by 2-bromopalmitate reproduces the Tip1- mutant phenotype Arabidopsis thaliana
additional information TIP1 encodes an ankyrin repeat protein with a DHHC Cys-rich domain Arabidopsis thaliana
physiological function S-acylation is a reversible hydrophobic protein modification that offers swift, flexible control of protein hydrophobicity and affects protein association with membranes, signal transduction, and vesicle trafficking within cells. S-acylation is essential for normal plant cell growth. TIP1 binds the acyl group palmitate and it can rescue the morphological, temperature sensitivity, and yeast casein kinase2 localization defects of the yeast S-acyl transferase mutant akr1DELTA Arabidopsis thaliana