Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | glucocorticoids and fibroblast growth factor induce the enzyme | Mus musculus | |
additional information | glucocorticoids and fibroblast growth factor induce the enzyme | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
LPCAT, DNA and amino acid sequence determination and analysis, functional expression in COS-7 cells and HEK-293 cells | Mus musculus |
LPCAT, DNA and amino acid sequence determination and analysis, functional expression in COS-7 cells and HEK-293 cells | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | the enzyme contains a transmembrane domain | Mus musculus | 16020 | - |
membrane | the enzyme contains a transmembrane domain | Rattus norvegicus | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
59000 | - |
x * 59000, recombinant enzyme, SDS-PAGE | Mus musculus |
63000 | - |
x * 63000, recombinant enzyme, SDS-PAGE | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | the enzyme is involved in dipalmitoylphosphatidylcholine synthesis | ? | - |
? | |
additional information | Rattus norvegicus | the enzyme is involved in dipalmitoylphosphatidylcholine synthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q3TFD2 | - |
- |
Rattus norvegicus | Q1HAQ0 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
alveolar type II cell | - |
Mus musculus | - |
alveolar type II cell | - |
Rattus norvegicus | - |
brain | low expression level | Mus musculus | - |
brain | low expression level | Rattus norvegicus | - |
intestine | low expression level | Rattus norvegicus | - |
lung | LPCAT is predominantly expressed in the lung | Mus musculus | - |
lung | LPCAT is predominantly expressed in the lung, LPCAT expression in the developing and adult lung, overview | Rattus norvegicus | - |
additional information | expression tissue distribution, overview | Mus musculus | - |
additional information | expression tissue distribution, overview | Rattus norvegicus | - |
spleen | - |
Mus musculus | - |
spleen | low expression level | Rattus norvegicus | - |
stomach | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is involved in dipalmitoylphosphatidylcholine synthesis | Mus musculus | ? | - |
? | |
additional information | the enzyme is involved in dipalmitoylphosphatidylcholine synthesis | Rattus norvegicus | ? | - |
? | |
additional information | substrate specificity, LPCAT prefers lysophosphatidylcholine as a substrate over lysophosphatidic acid, lysophosphatidylinositol, lysophosphatidylserine, lysophosphatidylethanolamine, or lysophosphatidylglycerol, and prefers palmitoyl-CoA to oleoyl-CoA as the acyl donor, the enzyme is involved in synthesis of membrane surfactant proteins and regulation of surfactant phospholipid biosynthesis | Mus musculus | ? | - |
? | |
additional information | substrate specificity, LPCAT prefers lysophosphatidylcholine as a substrate over lysophosphatidic acid, lysophosphatidylinositol, lysophosphatidylserine, lysophosphatidylethanolamine, or lysophosphatidylglycerol, and prefers palmitoyl-CoA to oleoyl-CoA as the acyl donor, the enzyme is involved in synthesis of membrane surfactant proteins and regulation of surfactant phospholipid biosynthesis | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 63000, recombinant enzyme, SDS-PAGE | Rattus norvegicus |
? | x * 59000, recombinant enzyme, SDS-PAGE | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
LPCAT | - |
Mus musculus |
LPCAT | - |
Rattus norvegicus |
lysoPC acyltransferase | - |
Mus musculus |
lysoPC acyltransferase | - |
Rattus norvegicus |
lysophosphatidylcholine acyltransferase | - |
Mus musculus |
lysophosphatidylcholine acyltransferase | - |
Rattus norvegicus |