Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q3TFD2 | isoform LPCAT1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | - |
Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | generation of mice bearing a hypomorphic allele of isoform Lpcat1. Newborn Lpcat1 hypomorphic mice show varying perinatal mortality from respiratory failure, with affected animals demonstrating hallmarks of respiratory distress such as atelectasis and hyaline membranes. Lpcat1 mRNA levels are reduced in newborn Lpcat1 hypomorphic mice and directly correlate with saturated phosphatidylcholine content, LPCAT1 activity, and survival. Surfactant isolated from dead Lpcat1 hypomorphic mice fails to reduce minimum surface tension to wild-type levels. Full LPCAT1 activity is required to achieve the levels of saturated phosphatidylcholine essential for the transition to air breathing | Mus musculus |