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Literature summary for 2.3.1.237 extracted from

  • Sthapit, B.; Oh, T.J.; Lamichhane, R.; Liou, K.; Lee, H.C.; Kim, C.G.; Sohng, J.K.
    Neocarzinostatin naphthoate synthase: an unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus (2004), FEBS Lett., 566, 201-206.
    View publication on PubMed
Search for more literature for 2.3.1.237

Cloned(Commentary)

Cloned (Comment) Organism
expression in Streptomyces lividans TK24 and Streptomyces coelicolor YU105 Streptomyces carzinostaticus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+ Streptomyces carzinostaticus the enzyme is involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus 2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
-
 ?
acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+ Streptomyces carzinostaticus ATCC 15944 the enzyme is involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus 2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces carzinostaticus
-
-
-
Streptomyces carzinostaticus ATCC 15944
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+
-
 Streptomyces carzinostaticus 2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
-
 ?
acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+ the enzyme is involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus Streptomyces carzinostaticus 2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
-
 ?
acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+
-
 Streptomyces carzinostaticus ATCC 15944 2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
-
 ?
acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+ the enzyme is involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus Streptomyces carzinostaticus ATCC 15944 2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
-
 ?

Synonyms

Synonyms Comment Organism
ncsB
-
 Streptomyces carzinostaticus
NNS
-
 Streptomyces carzinostaticus

General Information

General Information Comment Organism
metabolism the enzyme is involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus Streptomyces carzinostaticus