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Literature summary for 2.3.1.257 extracted from

  • Pavlou, D.; Kirmizis, A.
    Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway (2015), Apoptosis, 21, 298-311.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.257

Application

Application Comment Organism
medicine the enzyme is a therapeutic target in colorectal cancers Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + an N-terminal-L-seryl-[histone H2A] Homo sapiens
-
 an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-seryl-[histone H4] Homo sapiens
-
 an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens Q86UY6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell
-
 Homo sapiens
-
HCT-116 cell
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + an N-terminal-L-seryl-[histone H2A]
-
 Homo sapiens an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA
-
 ?
acetyl-CoA + an N-terminal-L-seryl-[histone H4]
-
 Homo sapiens an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA
-
 ?

Synonyms

Synonyms Comment Organism
N(alpha)-acetyltransferase 40
-
 Homo sapiens
Naa40
-
 Homo sapiens
NAT4
-
 Homo sapiens
NatD
-
 Homo sapiens
Patt1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction depletion of Naa40 in HCT-116 and HT-29 colorectal cancer cells decreases cell survival by enhancing apoptosis. Naa40 knockdown in colon cancer cells activates the mitochondrial caspase-9-mediated apoptotic cascade Homo sapiens