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Literature summary for 2.3.1.28 extracted from

  • Shaw, W.V.; Brodsky, R.F.
    Characterization of chloramphenicol acetyltransferase from chloramphenicol-resistant Staphylococcus aureus (1968), J. Bacteriol., 95, 28-36.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0027
-
chloramphenicol
-
Staphylococcus aureus
0.0037
-
D-threo-1-p-nitrophenyl-2-bromoacetamido-1,3-propanediol
-
Escherichia coli
0.0061
-
chloramphenicol
-
Escherichia coli
0.021
-
D-threo-1-phenyl-2-dichloroacetamido-1,3-propanediol
-
Escherichia coli
0.022
-
D-threo-1-p-nitrophenyl-2-bromoacetamido-1,3-propanediol
-
Staphylococcus aureus
0.068
-
D-threo-1-phenyl-2-dichloroacetamido-1,3-propanediol
-
Staphylococcus aureus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
78000
-
sucrose density gradient centrifugation Staphylococcus aureus
78000
-
sucrose density gradient centrifugation Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + chloramphenicol Staphylococcus aureus inducible enzyme CoA + chloramphenicol 3-acetate
-
?
acetyl-CoA + chloramphenicol Staphylococcus aureus inactivates chloramphenicol CoA + chloramphenicol 3-acetate
-
?
acetyl-CoA + chloramphenicol Escherichia coli inactivates chloramphenicol CoA + chloramphenicol 3-acetate
-
?
acetyl-CoA + chloramphenicol Staphylococcus aureus C22.1 inducible enzyme CoA + chloramphenicol 3-acetate
-
?
acetyl-CoA + chloramphenicol Staphylococcus aureus C22.1 inactivates chloramphenicol CoA + chloramphenicol 3-acetate
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Staphylococcus aureus
-
-
-
Staphylococcus aureus C22.1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 acetyl-CoA + chloramphenicol
-
Staphylococcus aureus 2 CoA + chloramphenicol 1,3-diacetate
-
?
acetyl-CoA + chloramphenicol
-
Escherichia coli CoA + chloramphenicol 3-acetate
-
?
acetyl-CoA + chloramphenicol acetylates only the biologically active D-threo stereoisomer Staphylococcus aureus CoA + chloramphenicol 3-acetate + chloramphenicol 1,3-diacetate ?
acetyl-CoA + chloramphenicol inducible enzyme Staphylococcus aureus CoA + chloramphenicol 3-acetate
-
?
acetyl-CoA + chloramphenicol inactivates chloramphenicol Staphylococcus aureus CoA + chloramphenicol 3-acetate
-
?
acetyl-CoA + chloramphenicol inactivates chloramphenicol Escherichia coli CoA + chloramphenicol 3-acetate
-
?
acetyl-CoA + chloramphenicol acetylates only the biologically active D-threo stereoisomer Staphylococcus aureus C22.1 CoA + chloramphenicol 3-acetate + chloramphenicol 1,3-diacetate ?
acetyl-CoA + chloramphenicol inducible enzyme Staphylococcus aureus C22.1 CoA + chloramphenicol 3-acetate
-
?
acetyl-CoA + chloramphenicol inactivates chloramphenicol Staphylococcus aureus C22.1 CoA + chloramphenicol 3-acetate
-
?
acetyl-CoA + D-threo-1-p-nitrophenyl-2-bromoacetamido-1,3-propanediol
-
Staphylococcus aureus CoA + ?
-
?
acetyl-CoA + D-threo-1-p-nitrophenyl-2-bromoacetamido-1,3-propanediol
-
Escherichia coli CoA + ?
-
?
acetyl-CoA + D-threo-1-p-nitrophenyl-2-bromoacetamido-1,3-propanediol
-
Staphylococcus aureus C22.1 CoA + ?
-
?
acetyl-CoA + D-threo-1-phenyl-2-dichloroacetamido-1,3-propanediol
-
Staphylococcus aureus CoA + ?
-
?
acetyl-CoA + D-threo-1-phenyl-2-dichloroacetamido-1,3-propanediol
-
Escherichia coli CoA + ?
-
?
acetyl-CoA + D-threo-1-phenyl-2-dichloroacetamido-1,3-propanediol
-
Staphylococcus aureus C22.1 CoA + ?
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
75
-
rapid inactivation Escherichia coli
75
-
remarkably resistant Staphylococcus aureus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
-
Staphylococcus aureus
7.8
-
-
Escherichia coli

pH Range

pH Minimum pH Maximum Comment Organism
6 8.8 pH 6.0: about 55% of maximal activity, pH 8.8: about 85% of maximal activity Staphylococcus aureus