Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | iron depletion does not increase isoform II promotor activity | Mus musculus | |
O2 | 1%, 3fold increase in expression level, promotor activation in transiently transfected HeLa cells, hypoxia-inducible erythroid-isoform | Mus musculus |
Cloned (Comment) | Organism |
---|---|
transient expression of erythroid-specific isoform and promotor-mutant in HeLa cells, luciferase reporter gene | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | site-directed mutagenesis of hypoxia-inducible factor-1, i.e. HIF-1, binding site in promotor sequence -328/-318, reveales HIF-1 like activation of enzyme expression during hypoxia | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinyl-CoA + glycine | Mus musculus | rate-limiting enzyme of heme biosynthesis | 5-aminolevulinate + CoA + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
erythroid-specific isoform | - |
Mus musculus | - |
gene ALAS-2 | - |
Mus musculus | - |
hypoxia-inducible | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythroleukemia cell line | erythroid-specific isoform | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
succinyl-CoA + glycine | - |
Mus musculus | 5-aminolevulinate + CoA + CO2 | - |
? | |
succinyl-CoA + glycine | rate-limiting enzyme of heme biosynthesis | Mus musculus | 5-aminolevulinate + CoA + CO2 | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Mus musculus |