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Literature summary for 2.3.1.37 extracted from

  • Hunter, G.A.; Ferreira, G.C.
    Lysine-313 of 5-aminolevulinate synthase acts as a general base during formation of the quinonoid reaction intermediates (1999), Biochemistry, 38, 3711-3718.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
K313H formation of quinonoid reaction intermediates Mus musculus
K313R formation of quinonoid reaction intermediates Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinyl-CoA + glycine Mus musculus first step in heme biosynthesis pathway 5-aminolevulinate + CoA + CO2
-
?
succinyl-CoA + glycine Mus musculus rate-limiting enzyme of heme biosynthesis 5-aminolevulinate + CoA + CO2
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
erythroid-specific isoform
-

Reaction

Reaction Comment Organism Reaction ID
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 mechanism Mus musculus
succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2 Lys313 acts as a general base during formation of the quinonoid reaction intermediates Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinyl-CoA + glycine
-
Mus musculus 5-aminolevulinate + CoA + CO2
-
?
succinyl-CoA + glycine first step in heme biosynthesis pathway Mus musculus 5-aminolevulinate + CoA + CO2
-
?
succinyl-CoA + glycine rate-limiting enzyme of heme biosynthesis Mus musculus 5-aminolevulinate + CoA + CO2
-
?

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Mus musculus