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Literature summary for 2.3.1.47 extracted from

  • Cho, J.; Kang, S.; Choi, J.; Ko, Y.; Hwang, I.; Kang, N.
    The identification of binding mode for Arabidopsis thaliana 7-keto-8-aminopelargonic acid synthase (AtKAPAS) inhibitors (2012), Bull. Korean Chem. Soc., 33, 1597-1602.
No PubMed abstract available
Search for more literature for 2.3.1.47

Inhibitors

Inhibitors Comment Organism Structure
2,3-dichloronaphthalene-1,4-dione
-
 Arabidopsis thaliana
2-(furan-2-yl)-1H-benzimidazole
-
 Arabidopsis thaliana
2-[(1,1,2,2-tetrachloroethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione
-
 Arabidopsis thaliana
2-[(trichloromethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione
-
 Arabidopsis thaliana
4-(1H-inden-3-yl)naphthalene-1,2-dione
-
 Arabidopsis thaliana
5,10-dioxo-5,10-dihydronaphtho[2,3-b][1,4]dithiine-2,3-dicarbonitrile
-
 Arabidopsis thaliana
5,8-dihydronaphthalene-1,4-dione
-
 Arabidopsis thaliana
5,8-dihydroxynaphthalene-1,4-dione
-
 Arabidopsis thaliana
5-hydroxy-2-methylnaphthalene-1,4-dione
-
 Arabidopsis thaliana
5-hydroxynaphthalene-1,4-dione
-
 Arabidopsis thaliana
methyl 3-(5,6-dioxo-5,6-dihydronaphthalen-2-yl)propanoate
-
 Arabidopsis thaliana
methyl 3-[8-(1H-inden-3-yl)-5,6-dioxo-5,6-dihydronaphthalen-2-yl]propanoate
-
 Arabidopsis thaliana
methyl 3-[8-[(4-fluorophenyl)amino]-5,6-dioxo-5,6-dihydronaphthalen-2-yl]propanoate
-
 Arabidopsis thaliana
methyl 3-[8-[(4-methylphenyl)amino]-5,6-dioxo-5,6-dihydronaphthalen-2-yl]propanoate
-
 Arabidopsis thaliana
N-[dichloro(fluoro)-l4-sulfanyl]-N',N'-dimethyl-N-phenylsulfuric diamide
-
 Arabidopsis thaliana
N-[dichloro(fluoromethyl)-lambda4-sulfanyl]-N',N'-dimethyl-N-(4-methylphenyl)sulfuric diamide
-
 Arabidopsis thaliana
naphthalene-1,2-dione
-
 Arabidopsis thaliana

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-alanine + pimeloyl-CoA
-
 Arabidopsis thaliana 8-amino-7-oxononanoate + CoA + CO2
-
 ?

Synonyms

Synonyms Comment Organism
7-keto-8-aminopelargonic acid synthase
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Arabidopsis thaliana

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00059
-
 pH 7.5, 30°C Arabidopsis thaliana methyl 3-[8-[(4-methylphenyl)amino]-5,6-dioxo-5,6-dihydronaphthalen-2-yl]propanoate
0.00063
-
 pH 7.5, 30°C Arabidopsis thaliana methyl 3-[8-[(4-fluorophenyl)amino]-5,6-dioxo-5,6-dihydronaphthalen-2-yl]propanoate
0.0011
-
 pH 7.5, 30°C Arabidopsis thaliana methyl 3-[8-(1H-inden-3-yl)-5,6-dioxo-5,6-dihydronaphthalen-2-yl]propanoate
0.0013
-
 pH 7.5, 30°C Arabidopsis thaliana 4-(1H-inden-3-yl)naphthalene-1,2-dione
0.0021
-
 pH 7.5, 30°C Arabidopsis thaliana 5-hydroxy-2-methylnaphthalene-1,4-dione
0.0033
-
 pH 7.5, 30°C Arabidopsis thaliana naphthalene-1,2-dione
0.0044
-
 pH 7.5, 30°C Arabidopsis thaliana 5,8-dihydroxynaphthalene-1,4-dione
0.0044
-
 pH 7.5, 30°C Arabidopsis thaliana 5,8-dihydronaphthalene-1,4-dione
0.0044
-
 pH 7.5, 30°C Arabidopsis thaliana methyl 3-(5,6-dioxo-5,6-dihydronaphthalen-2-yl)propanoate
0.0096
-
 pH 7.5, 30°C Arabidopsis thaliana 5-hydroxynaphthalene-1,4-dione
0.011
-
 pH 7.5, 30°C Arabidopsis thaliana 2,3-dichloronaphthalene-1,4-dione
0.011
-
 pH 7.5, 30°C Arabidopsis thaliana 5,10-dioxo-5,10-dihydronaphtho[2,3-b][1,4]dithiine-2,3-dicarbonitrile
0.041
-
 pH 7.5, 30°C Arabidopsis thaliana N-[dichloro(fluoro)-l4-sulfanyl]-N',N'-dimethyl-N-phenylsulfuric diamide
0.042
-
 pH 7.5, 30°C Arabidopsis thaliana 2-(furan-2-yl)-1H-benzimidazole
0.047
-
 pH 7.5, 30°C Arabidopsis thaliana N-[dichloro(fluoromethyl)-lambda4-sulfanyl]-N',N'-dimethyl-N-(4-methylphenyl)sulfuric diamide
0.054
-
 pH 7.5, 30°C Arabidopsis thaliana 2-[(trichloromethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione
0.056
-
 pH 7.5, 30°C Arabidopsis thaliana 2-[(1,1,2,2-tetrachloroethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione