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Literature summary for 2.3.1.48 extracted from

  • Wiegand, R.C.; Brutlag, D.L.
    Histone acetylase from Drosophila melanogaster specific for H4 (1981), J. Biol. Chem., 256, 4578-4583.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Brij-58
-
Drosophila melanogaster
CoA
-
Drosophila melanogaster
DNA dsDNA Drosophila melanogaster
histone histones H2A, H2B, and H3 Drosophila melanogaster
histone H4
-
Drosophila melanogaster
Nonidet P40
-
Drosophila melanogaster
Polyarginine
-
Drosophila melanogaster
Polyglutamic acid
-
Drosophila melanogaster
polylysine
-
Drosophila melanogaster
potassium phosphate 90 mM Drosophila melanogaster
protamine
-
Drosophila melanogaster
RNA
-
Drosophila melanogaster
Triton X-100
-
Drosophila melanogaster

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Drosophila melanogaster

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
160000
-
nondenaturing PAGE Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + histone Drosophila melanogaster most likely involved in acetylation of newly synthesized histones in cytoplasm prior to chromatin assembly CoA + acetylhistone
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Drosophila melanogaster

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
Drosophila melanogaster
-
hepatoma cell tissue culture cell, HTC cells Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone
-
Drosophila melanogaster CoA + acetylhistone
-
?
acetyl-CoA + histone most likely involved in acetylation of newly synthesized histones in cytoplasm prior to chromatin assembly Drosophila melanogaster CoA + acetylhistone
-
?
acetyl-CoA + histone H4 highly specific for Drosophila melanogaster CoA + acetylhistone H4
-
?
acetyl-CoA + histone H4 histone H4: all of the acetate groups are introduced within the NH2-terminal amino acids 4 to 17 Drosophila melanogaster CoA + acetylhistone H4
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
1 min, irreversible denaturation Drosophila melanogaster

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
-
Drosophila melanogaster

pH Stability

pH Stability pH Stability Maximum Comment Organism
6.5
-
rapid loss of activity below Drosophila melanogaster