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Literature summary for 2.3.1.48 extracted from

  • Berger, S.L.
    Gene activation by histone and factor acetyltransferases (1999), Curr. Opin. Cell Biol., 11, 336-341.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information
-
Saccharomyces cerevisiae
additional information mutations that reduce histone acetylation activity also lower the transcriptional activation function of a Gal4-CBP fusion protein in vivo Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
model of protein complex composition Homo sapiens
additional information
-
model of protein complex composition Saccharomyces cerevisiae
additional information
-
enzyme is part of a bridging complex, containing Ada2 and Ada3, for gene activation Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + histone Homo sapiens neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA CoA + acetylhistone
-
?
acetyl-CoA + histone Saccharomyces cerevisiae neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA CoA + acetylhistone
-
?
acetyl-CoA + histone Tetrahymena sp. neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA CoA + acetylhistone
-
?
acetyl-CoA + histone Homo sapiens the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling CoA + acetylhistone
-
?
acetyl-CoA + histone Saccharomyces cerevisiae the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling CoA + acetylhistone
-
?
acetyl-CoA + histone Tetrahymena sp. the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling CoA + acetylhistone
-
?
acetyl-CoA + histone Homo sapiens GCN5 neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA CoA + acetylhistone
-
?
acetyl-CoA + histone Homo sapiens GCN5 the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling CoA + acetylhistone
-
?
additional information Homo sapiens enzyme activity is regulated by phosphorylation and interaction with other regulating protein factors ?
-
?
additional information Saccharomyces cerevisiae enzyme activity is regulated by phosphorylation and interaction with other regulating protein factors ?
-
?
additional information Homo sapiens GCN5 enzyme activity is regulated by phosphorylation and interaction with other regulating protein factors ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
GCN5
-
Homo sapiens
-
recombinant enzyme hPCAF, i.e. human p300/CBP associated factor
-
Homo sapiens GCN5
-
GCN5
-
Saccharomyces cerevisiae
-
gene Gcn5
-
Tetrahymena sp.
-
protein p55
-

Reaction

Reaction Comment Organism Reaction ID
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine mechanisms Homo sapiens
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine mechanisms Saccharomyces cerevisiae
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine enzymes are also active as transcription coactivators and corepressors of transcription factors in gene regulation, acetylation of transcription factors, overview Homo sapiens
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine enzymes are also active as transcription coactivators and corepressors of transcription factors in gene regulation, acetylation of transcription factors, overview Saccharomyces cerevisiae
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine enzymes are also active as transcription coactivators and corepressors of transcription factors in gene regulation, acetylation of transcription factors, overview Tetrahymena sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + histone
-
Tetrahymena sp. CoA + acetylhistone
-
?
acetyl-CoA + histone a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms Homo sapiens CoA + acetylhistone
-
?
acetyl-CoA + histone a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms Saccharomyces cerevisiae CoA + acetylhistone
-
?
acetyl-CoA + histone neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA Homo sapiens CoA + acetylhistone
-
?
acetyl-CoA + histone neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA Saccharomyces cerevisiae CoA + acetylhistone
-
?
acetyl-CoA + histone neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA Tetrahymena sp. CoA + acetylhistone
-
?
acetyl-CoA + histone the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling Homo sapiens CoA + acetylhistone
-
?
acetyl-CoA + histone the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling Saccharomyces cerevisiae CoA + acetylhistone
-
?
acetyl-CoA + histone the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling Tetrahymena sp. CoA + acetylhistone
-
?
acetyl-CoA + histone a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms Homo sapiens GCN5 CoA + acetylhistone
-
?
acetyl-CoA + histone neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA Homo sapiens GCN5 CoA + acetylhistone
-
?
acetyl-CoA + histone the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling Homo sapiens GCN5 CoA + acetylhistone
-
?
acetyl-CoA + histone H2A
-
Homo sapiens CoA + acetylhistone H2A
-
?
acetyl-CoA + histone H2A
-
Saccharomyces cerevisiae CoA + acetylhistone H2A
-
?
acetyl-CoA + histone H2B
-
Homo sapiens CoA + acetylhistone H2B
-
?
acetyl-CoA + histone H2B
-
Saccharomyces cerevisiae CoA + acetylhistone H2B
-
?
acetyl-CoA + histone H3
-
Homo sapiens CoA + acetylhistone H3
-
?
acetyl-CoA + histone H3 histone H3: preferred substrate Saccharomyces cerevisiae CoA + acetylhistone H3
-
?
acetyl-CoA + histone H4
-
Homo sapiens CoA + acetylhistone H4
-
?
acetyl-CoA + histone H4
-
Saccharomyces cerevisiae CoA + acetylhistone H4
-
?
acetyl-CoA + protein p53 substrate is a DNA-binding transcription activator and a tumor suppressor Homo sapiens CoA + acetylprotein p53
-
?
acetyl-CoA + transcription factor TFIIE substrate is a basal transcription factor Homo sapiens CoA + acetylated transcription factor TFIIE
-
?
acetyl-CoA + transcription factor TFIIF substrate is a basal transcription factor Homo sapiens CoA + acetylated transcription factor TFIIF
-
?
additional information Gcn5 and PCAF protein are transcription cofactors Homo sapiens ?
-
?
additional information Gcn5 and PCAF protein are transcription cofactors Saccharomyces cerevisiae ?
-
?
additional information enzyme activity is regulated by phosphorylation and interaction with other regulating protein factors Homo sapiens ?
-
?
additional information enzyme activity is regulated by phosphorylation and interaction with other regulating protein factors Saccharomyces cerevisiae ?
-
?
additional information Gcn5 and PCAF protein are transcription cofactors Homo sapiens GCN5 ?
-
?
additional information enzyme activity is regulated by phosphorylation and interaction with other regulating protein factors Homo sapiens GCN5 ?
-
?

Synonyms

Synonyms Comment Organism
HAT
-
Homo sapiens
HAT
-
Saccharomyces cerevisiae
HAT
-
Tetrahymena sp.
More enzymes with histone acetyltransferase and transcription cofactor activity belong to the MYST protein family Homo sapiens
More enzymes with histone acetyltransferase and transcription cofactor activity belong to the MYST protein family Saccharomyces cerevisiae
More enzymes with histone acetyltransferase and transcription cofactor activity belong to the MYST protein family Tetrahymena sp.