Protein Variants | Comment | Organism |
---|---|---|
additional information | - |
Saccharomyces cerevisiae |
additional information | mutations that reduce histone acetylation activity also lower the transcriptional activation function of a Gal4-CBP fusion protein in vivo | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
model of protein complex composition | Homo sapiens |
additional information | - |
model of protein complex composition | Saccharomyces cerevisiae |
additional information | - |
enzyme is part of a bridging complex, containing Ada2 and Ada3, for gene activation | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone | Homo sapiens | neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | Saccharomyces cerevisiae | neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | Tetrahymena sp. | neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | Homo sapiens | the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | Saccharomyces cerevisiae | the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | Tetrahymena sp. | the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | Homo sapiens GCN5 | neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | Homo sapiens GCN5 | the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling | CoA + acetylhistone | - |
? | |
additional information | Homo sapiens | enzyme activity is regulated by phosphorylation and interaction with other regulating protein factors | ? | - |
? | |
additional information | Saccharomyces cerevisiae | enzyme activity is regulated by phosphorylation and interaction with other regulating protein factors | ? | - |
? | |
additional information | Homo sapiens GCN5 | enzyme activity is regulated by phosphorylation and interaction with other regulating protein factors | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
GCN5 | - |
Homo sapiens | - |
recombinant enzyme hPCAF, i.e. human p300/CBP associated factor | - |
Homo sapiens GCN5 | - |
GCN5 | - |
Saccharomyces cerevisiae | - |
gene Gcn5 | - |
Tetrahymena sp. | - |
protein p55 | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine | mechanisms | Homo sapiens | |
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine | mechanisms | Saccharomyces cerevisiae | |
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine | enzymes are also active as transcription coactivators and corepressors of transcription factors in gene regulation, acetylation of transcription factors, overview | Homo sapiens | |
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine | enzymes are also active as transcription coactivators and corepressors of transcription factors in gene regulation, acetylation of transcription factors, overview | Saccharomyces cerevisiae | |
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine | enzymes are also active as transcription coactivators and corepressors of transcription factors in gene regulation, acetylation of transcription factors, overview | Tetrahymena sp. |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + histone | - |
Tetrahymena sp. | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms | Homo sapiens | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms | Saccharomyces cerevisiae | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA | Homo sapiens | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA | Saccharomyces cerevisiae | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA | Tetrahymena sp. | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling | Homo sapiens | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling | Saccharomyces cerevisiae | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling | Tetrahymena sp. | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | a group of enzymes with differing specificity towards histone acceptors, specificity of different enzyme forms | Homo sapiens GCN5 | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | neutralization of positively charged lysine residues by acetylation lowering the affinity of histone octamers for the negatively charged DNA | Homo sapiens GCN5 | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone | the acetyl groups function as signals for interaction of histones with other regulatory proteins, chromatin remodeling | Homo sapiens GCN5 | CoA + acetylhistone | - |
? | |
acetyl-CoA + histone H2A | - |
Homo sapiens | CoA + acetylhistone H2A | - |
? | |
acetyl-CoA + histone H2A | - |
Saccharomyces cerevisiae | CoA + acetylhistone H2A | - |
? | |
acetyl-CoA + histone H2B | - |
Homo sapiens | CoA + acetylhistone H2B | - |
? | |
acetyl-CoA + histone H2B | - |
Saccharomyces cerevisiae | CoA + acetylhistone H2B | - |
? | |
acetyl-CoA + histone H3 | - |
Homo sapiens | CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H3 | histone H3: preferred substrate | Saccharomyces cerevisiae | CoA + acetylhistone H3 | - |
? | |
acetyl-CoA + histone H4 | - |
Homo sapiens | CoA + acetylhistone H4 | - |
? | |
acetyl-CoA + histone H4 | - |
Saccharomyces cerevisiae | CoA + acetylhistone H4 | - |
? | |
acetyl-CoA + protein p53 | substrate is a DNA-binding transcription activator and a tumor suppressor | Homo sapiens | CoA + acetylprotein p53 | - |
? | |
acetyl-CoA + transcription factor TFIIE | substrate is a basal transcription factor | Homo sapiens | CoA + acetylated transcription factor TFIIE | - |
? | |
acetyl-CoA + transcription factor TFIIF | substrate is a basal transcription factor | Homo sapiens | CoA + acetylated transcription factor TFIIF | - |
? | |
additional information | Gcn5 and PCAF protein are transcription cofactors | Homo sapiens | ? | - |
? | |
additional information | Gcn5 and PCAF protein are transcription cofactors | Saccharomyces cerevisiae | ? | - |
? | |
additional information | enzyme activity is regulated by phosphorylation and interaction with other regulating protein factors | Homo sapiens | ? | - |
? | |
additional information | enzyme activity is regulated by phosphorylation and interaction with other regulating protein factors | Saccharomyces cerevisiae | ? | - |
? | |
additional information | Gcn5 and PCAF protein are transcription cofactors | Homo sapiens GCN5 | ? | - |
? | |
additional information | enzyme activity is regulated by phosphorylation and interaction with other regulating protein factors | Homo sapiens GCN5 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HAT | - |
Homo sapiens |
HAT | - |
Saccharomyces cerevisiae |
HAT | - |
Tetrahymena sp. |
More | enzymes with histone acetyltransferase and transcription cofactor activity belong to the MYST protein family | Homo sapiens |
More | enzymes with histone acetyltransferase and transcription cofactor activity belong to the MYST protein family | Saccharomyces cerevisiae |
More | enzymes with histone acetyltransferase and transcription cofactor activity belong to the MYST protein family | Tetrahymena sp. |