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Literature summary for 2.3.1.5 extracted from

  • Minchin, R.F.; Hanna, P.E.; Dupret, J.M.; Wagner, C.R.; Rodrigues-Lima, F.; Butcher, N.J.
    Molecules in focus. Arylamine N-acetyltransferase I (2007), Int. J. Biochem. Cell Biol., 39, 1999-2005.
    View publication on PubMed
Search for more literature for 2.3.1.5

Cloned(Commentary)

Cloned (Comment) Organism
gene NAT1, DNA and amino acid sequence determination and analysis, genetic organization, several splice variants of the NAT1 gene that are expressed from different promoters, expression analysis, the NAT1 gene is located on chromosome 8 at 8p21-22, a region known to be deleted in many human cancers Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information mutations responsible for reduced NAT1 stability and down-regulation occur in nature, the NAT1 slow acetylator phenotype is associated with a protection against spina bifida, a condition that is linked to the level of maternal folic acid intake Homo sapiens
additional information NAT1*10, phenotype has higher than normal activity in some tissues, associated with increased risk of cancer Homo sapiens
additional information NAT1*14, slow acetylator phenotype, loss of function alleles Homo sapiens
additional information NAT1*15, slow acetylator phenotype, loss of function alleles Homo sapiens
additional information NAT1*17, slow acetylator phenotype, loss of function alleles Homo sapiens
additional information NAT1*19, slow acetylator phenotype, loss of function alleles Homo sapiens
additional information NAT1*22, slow acetylator phenotype, loss of function alleles Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
soluble
-
 Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33000
-
-
 Homo sapiens
33000
-
 x * 33000, soluble NAT1, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + an arylamine Homo sapiens
-
 CoA + an N-acetylarylamine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P18440 isozyme NAT1; isozyme NAT1
-

Reaction

Reaction Comment Organism Reaction ID
acetyl-CoA + an arylamine = CoA + an N-acetylarylamine molecular mechanism of arylamine acetylation by the catalytic triad of NAT1, overview, the catalytic triad is formed by Cys68, His107, and Asp122 Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + an arylamine
-
 Homo sapiens CoA + an N-acetylarylamine
-
 ?

Subunits

Subunits Comment Organism
? x * 33000, soluble NAT1, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
arylamine N-acetyltransferase I
-
 Homo sapiens
NAT
-
 Homo sapiens
NAT1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
 Homo sapiens