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Literature summary for 2.3.1.5 extracted from

  • Loehle, J.A.; Cornish, V.; Wakefield, L.; Doll, M.A.; Neale, J.R.; Zang, Y.; Sim, E.; Hein, D.W.
    N-acetyltransferase (Nat) 1 and 2 expression in Nat2 knockout mice (2006), J. Pharmacol. Exp. Ther., 319, 724-728.
    View publication on PubMed
Search for more literature for 2.3.1.5

Cloned(Commentary)

Cloned (Comment) Organism
tissue-specific expression analysis of isozyme NAT1 Mus musculus
tissue-specific expression analysis of isozyme NAT2 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of NAT2 knockout mice, phenotype, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + 4-aminobiphenyl Mus musculus substrate of isozyme NAT2 in liver cytosol N-acetyl-4-aminobiphenyl + CoA
-
 ?
acetyl-CoA + an arylamine Mus musculus
-
 CoA + an N-acetylarylamine
-
 ?
acetyl-CoA + N-hydroxy-4-aminobiphenyl Mus musculus substrate of isozyme NAT2 in liver cytosol N-acetyl-N-hydroxy-4-aminobiphenyl + CoA
-
 ?
additional information Mus musculus the isozymes catalyze the N-acetylation of aromatic amine and hydrazine drugs and carcinogens, after N-hydroxylation, they also catalyze the metabolic activation of N-hydroxy-arylamines via O-acetylation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P50294 isozyme NAT1; male mice, isozyme NAT1
-
Mus musculus P50295 isozyme NAT2; male mice, isozyme NAT2
-

Source Tissue

Source Tissue Comment Organism Textmining
bladder
-
 Mus musculus
-
gut
-
 Mus musculus
-
liver
-
 Mus musculus
-
additional information broad tissue distribution of isozyme NAT1, tissue-specific expression analysis of isozyme NAT1 Mus musculus
-
additional information broad tissue distribution of isozyme NAT2, tissue-specific expression analysis of isozymes NAT2 Mus musculus
-
pancreas
-
 Mus musculus
-
prostate gland
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 4-aminobenzoic acid
-
 Mus musculus CoA + N-acetyl-4-aminobenzoic acid
-
 ?
acetyl-CoA + 4-aminobiphenyl substrate of isozyme NAT2 in liver cytosol Mus musculus N-acetyl-4-aminobiphenyl + CoA
-
 ?
acetyl-CoA + 4-aminobiphenyl substrate of isozyme NAT2 Mus musculus N-acetyl-4-aminobiphenyl + CoA
-
 ?
acetyl-CoA + an arylamine
-
 Mus musculus CoA + an N-acetylarylamine
-
 ?
acetyl-CoA + isoniazid
-
 Mus musculus CoA + an N-acetylisoniazid
-
 ?
acetyl-CoA + N-hydroxy-4-aminobiphenyl substrate of isozyme NAT2 in liver cytosol Mus musculus N-acetyl-N-hydroxy-4-aminobiphenyl + CoA
-
 ?
acetyl-CoA + N-hydroxy-4-aminobiphenyl substrate of isozyme NAT2, O-acetylation activity of NAT2 Mus musculus N-hydroxy-O-acetyl-4-aminobiphenyl + CoA
-
 ?
additional information the isozymes catalyze the N-acetylation of aromatic amine and hydrazine drugs and carcinogens, after N-hydroxylation, they also catalyze the metabolic activation of N-hydroxy-arylamines via O-acetylation Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
NAT
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
 Mus musculus