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Literature summary for 2.3.1.5 extracted from

  • Laurieri, N.; Egleton, J.E.; Varney, A.; Thinnes, C.C.; Quevedo, C.E.; Seden, P.T.; Thompson, S.; Rodrigues-Lima, F.; Dairou, J.; Dupret, J.M.; Russell, A.J.; Sim, E.
    A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1 (2013), PLoS ONE, 8, e70600.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Rosetta(DE3)pLysS cells Mus musculus
expressed in Escherichia coli Rosetta(DE3)pLysS cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-[3-(3,5-dimethylanilino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]benzenesulfonamide 93.3% inhibition of isoform NAT1 at 0.03 mM and 10.6% inhibition of isoform NAT2 Homo sapiens
N-[3-(3,5-dimethylanilino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]benzenesulfonamide 37.6% inhibition of isoform Nat1 at 0.03 mM and 92.4% inhibition of isoform Nat2 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + an arylamine Mus musculus
-
CoA + an N-acetylarylamine
-
?
acetyl-CoA + an arylamine Homo sapiens
-
CoA + an N-acetylarylamine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Mus musculus
Ni-NTA column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + an arylamine
-
Mus musculus CoA + an N-acetylarylamine
-
?
acetyl-CoA + an arylamine
-
Homo sapiens CoA + an N-acetylarylamine
-
?

Synonyms

Synonyms Comment Organism
NAT1 isoform Mus musculus
NAT1 isoform Homo sapiens
NAT2 isoform Mus musculus
NAT2 isoform Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0019
-
isoform Nat2, pH and temperature not specified in the publication Mus musculus N-[3-(3,5-dimethylanilino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]benzenesulfonamide
0.0053
-
isoform NAT1, pH and temperature not specified in the publication Homo sapiens N-[3-(3,5-dimethylanilino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]benzenesulfonamide