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Literature summary for 2.3.1.51 extracted from

  • Blaskovich, M.A.; Yendluri, V.; Lawrence, H.R.; Lawrence, N.J.; Sebti, S.M.; Springett, G.M.
    Lysophosphatidic acid acyltransferase beta regulates mTOR signaling (2013), PLoS ONE, 8, e78632.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
oleoyl-CoA + 1-oleoyl-2-lysophosphatidylinositol Homo sapiens
-
CoA + 1,2-dioleoyl-sn-phosphatidylinositol
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AsPC-1 cell
-
Homo sapiens
-
MiaPaCa-2 cell
-
Homo sapiens
-
PANC-1 cell
-
Homo sapiens
-
pancreatic cancer cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
oleoyl-CoA + 1-oleoyl-2-lysophosphatidylinositol
-
Homo sapiens CoA + 1,2-dioleoyl-sn-phosphatidylinositol
-
?

Synonyms

Synonyms Comment Organism
LPAAT-beta
-
Homo sapiens
lysophosphatidic acid acyltransferase beta
-
Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme knockdown inhibits proliferation and anchorage-independent growth of pancreatic cancer cells Homo sapiens
physiological function the enzyme regulates mTOR signaling by affecting its association with FKBP38 and regulates nuclear shape and Lipin 1 nuclear localization Homo sapiens