Any feedback?
Literature summary for 2.3.1.57 extracted from
- Spermidine/spermine N1-acetyltransferase catalyzes amantadine acetylation (2001), Drug Metab. Dispos., 29, 676-680.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| transgenic CD2F1 mice overexpressing SSAT | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| amantadine | competitively inhibits spermidine acetylation, at 10 mM: complete inhibition | Mus musculus |  |
| additional information | not inhibited by p-aminobenzoic acid | Mus musculus | |
| sulfamethazine | inhibits spermidine acetylation | Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.267 | - |
spermidine | - |
Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + amantadine | Mus musculus | reaction occurs in vivo and in vitro, but only in presence of increased enzyme levels, amantadine may be a specific drug substrate for SSAT | CoA + N1-acetylamantadine | - |
? | |
| additional information | Mus musculus | polyamine catabolic enzyme | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
transgenic male CD2F1 mice overexpressing SSAT | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + amantadine | reaction occurs in vivo and in vitro, but only in presence of increased enzyme levels, amantadine may be a specific drug substrate for SSAT | Mus musculus | CoA + N1-acetylamantadine | - |
? | |
| acetyl-CoA + spermidine | - |
Mus musculus | CoA + N1-acetylspermidine | - |
? | |
| additional information | polyamine catabolic enzyme | Mus musculus | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.738 | - |
amantadine | - |
Mus musculus | |
| 3.5 | - |
sulfamethazine | - |
Mus musculus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
